Targeted colonic release formulations of mesalazine - A clinical pharmaco-scintigraphic proof-of-concept study in healthy subjects and patients with mildly active ulcerative colitis.

Varum, F; Thorne, H; Bravo, R; Gilgen, D; Hartig, C; Nicolas, G P; Wild, D; Liakoni, Ev; Haschke, M (2022). Targeted colonic release formulations of mesalazine - A clinical pharmaco-scintigraphic proof-of-concept study in healthy subjects and patients with mildly active ulcerative colitis. International journal of pharmaceutics, 625, p. 122055. Elsevier 10.1016/j.ijpharm.2022.122055

[img]
Preview
Text
1-s2.0-S0378517322006093-main.pdf - Accepted Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

Colonic targeting of orally applied therapeutic drugs remains a challenge. Tablet coatings relying on gastrointestinal pH and colonic bacterial enzymes as triggers in association with an inner alkaline layer are expected to improve targeting efficiency. Mesalazine release from three differently coated tablets labelled with 1 MBq 153Sm was characterised in a single centre, open-label, parallel group study in nineteen healthy subjects and seven patients with mildly active ulcerative colitis. Two semi-organic and one aqueous-based outer coating with different ratios of enteric polymer and resistant starch were tested. All coatings showed comparable release lagtimes in biorelevant dissolution media and were not affected by neutron-activation of the samarium tracer. Mesalazine pharmacokinetics and gamma scintigraphy were used to characterise drug release, anatomical site of tablet disintegration and gastrointestinal transit. Initial tablet disintegration occurred at the ileo-caecal junction or beyond in 92% of the subjects Time to initial tablet disintegration was inversely correlated with maximal plasma concentrations and systemic mesalazine exposure. Although high inter-subject variability precluded detection of differences between solvent types and different enteric polymer to polysaccharide ratios, the dual pH and enzymatic triggered release system in combination with an inner alkaline layer promoted mesalazine release at the target site with high accuracy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Liakoni, Evangelia and Haschke, Manuel Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0378-5173

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

05 Aug 2022 14:05

Last Modified:

10 Sep 2022 00:15

Publisher DOI:

10.1016/j.ijpharm.2022.122055

PubMed ID:

35926752

Uncontrolled Keywords:

Colonic delivery Mesalazine/Mesalamine/5-aminosalicylic acid OPTICORE Samarium Scintigraphy Ulcerative colitis

BORIS DOI:

10.48350/171755

URI:

https://boris.unibe.ch/id/eprint/171755

Actions (login required)

Edit item Edit item
Provide Feedback