Morbidity and Oncological Outcome After Curative Treatment in Sinonasal Squamous Cell Carcinoma.

Hohenberger, Ralph; Beckmann, Sven; Kaecker, Christoph; Eliçin, Olgun; Giger, Roland; Caversaccio, Marco; Anschuetz, Lukas (2022). Morbidity and Oncological Outcome After Curative Treatment in Sinonasal Squamous Cell Carcinoma. (In Press). Ear, nose, & throat journal(1455613221117787), p. 1455613221117787. Sage 10.1177/01455613221117787

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OBJECTIVES

Sinonasal squamous cell carcinomas are rare and aggressive tumors. Curative therapy includes surgery and radiotherapy, with high risk for local morbidity and impaired quality of life. The objective of this study was to analyze a large cohort of patients with sinonasal squamous cell carcinoma on treatment morbidity and oncological outcome.

METHODS

Patients with sinonasal squamous cell carcinoma (n = 75) treated at a tertiary referral center between 2008 and 2019 were identified. In patients with curative treatment intent (n = 70), a chart review and analysis on patient and tumor characteristics, morbidity, and oncological outcome was performed.

RESULTS

Mean follow-up was 59 months. Primary curative therapy was surgery alone (n = 18), surgery with radiation (n = 25), and primary (chemo)radiation (n = 27). Forty-two (60%) patients suffered from treatment-related morbidity; most frequent symptoms were dry nasal mucosa (20%), nasal obstruction (14.3%), and vision impairment or loss (11.5%). Patients with early disease had less morbidity (51.4 vs 71.1%; P = 0.09), a lower recurrence rate (27% vs. 48.5%; P = 0.08), and better overall survival (92.5% vs. 71.1%; P = 0.01).

CONCLUSION

Treatment-related morbidity is common after curative treatment of sinonasal squamous cell carcinomas. Early disease is beneficial in terms of occurrence and severity as multimodal treatment and recurrence can more likely be avoided.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Hohenberger, Ralph Christian; Beckmann, Sven; Käcker, Christoph; Eliçin, Olgun; Giger, Roland; Caversaccio, Marco and Anschütz, Lukas Peter

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1942-7522

Publisher:

Sage

Language:

English

Submitter:

Pubmed Import

Date Deposited:

10 Aug 2022 11:17

Last Modified:

11 Aug 2022 00:16

Publisher DOI:

10.1177/01455613221117787

PubMed ID:

35938196

Uncontrolled Keywords:

endoscopic sinus surgery endoscopy head and neck quality of life rhinology squamous cell carcinoma

BORIS DOI:

10.48350/171811

URI:

https://boris.unibe.ch/id/eprint/171811

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