Schneider, Tim; Fernandez-Palomo, Cristian; Bertho, Annaïg; Fazzari, Jennifer; Iturri, Lorea; Martin, Olga A; Trappetti, Verdiana; Djonov, Valentin; Prezado, Yolanda (2022). Combining FLASH and spatially fractionated radiation therapy: the best of both worlds. Radiotherapy and oncology, 175, pp. 169-177. Elsevier 10.1016/j.radonc.2022.08.004
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FLASH radiotherapy (FLASH-RT) and spatially fractionated radiation therapy (SFRT) are two new therapeutical strategies that use non-standard dose delivery methods to reduce normal tissue toxicity and increase the therapeutic index. Although likely based on different mechanisms, both FLASH-RT and SFRT have shown to elicit radiobiological effects that significantly differ from those induced by conventional radiotherapy. With the therapeutic potential having been established separately for each technique, the combination of FLASH-RT and SFRT could therefore represent a winning alliance. In this review, we discuss the state of the art, advantages and current limitations, potential synergies, and where a combination of these two techniques could be implemented today or in the near future.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy |
UniBE Contributor: |
Fernandez Palomo, Cristian Gabriel, Fazzari, Jennifer Michelina, Martin, Olga Alexeevna, Trappetti, Verdiana, Djonov, Valentin Georgiev |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0167-8140 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
12 Aug 2022 10:14 |
Last Modified: |
10 Aug 2023 00:25 |
Publisher DOI: |
10.1016/j.radonc.2022.08.004 |
PubMed ID: |
35952978 |
BORIS DOI: |
10.48350/171904 |
URI: |
https://boris.unibe.ch/id/eprint/171904 |
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