Righini, Marc; Robert-Ebadi, Helia; Cremonesi, Alessio; Elias, Antoine; Sanchez, Olivier; Le Moigne, Emmanuelle; Schmidt, Jeannot; Le Gall, Catherine; Cornuz, Jacques; Aujesky, Drahomir; Roy, Pierre-Marie; Chauleur, Céline; Rouyer, Frédéric; Poletti, Pierre-Alexandre; Moreau, Caroline; Le Gal, Grégoire (2022). Risk of neonatal hypothyroidism in newborns from mothers exposed to CTPA during pregnancy: ancillary data from a prospective outcome study. Journal of thrombosis and haemostasis, 20(11), pp. 2550-2555. Wiley-Blackwell 10.1111/jth.15843
|
Text
J_of_Thrombosis_Haemost_-_2022_-_Righini_-_Risk_of_neonatal_hypothyroidism_in_newborns_from_mothers_exposed_to_CTPA_during.pdf - Accepted Version Available under License Publisher holds Copyright. Download (355kB) | Preview |
BACKGROUND
Neonatal hypothyroidism is often raised as a potential concern for the use of Computed Tomography Pulmonary Angiography (CTPA) in pregnant women with suspected PE.
OBJECTIVES
To assess the incidence of neonatal hypothyroidism among newborns from mothers exposed to CTPA.
PATIENTS/METHODS
Pregnant women with clinically suspected PE, included in a multicentre multinational prospective diagnostic management outcome study, based on pretest clinical probability assessment, high-sensitivity D-dimer testing, bilateral lower limb venous compression ultrasonography, and computed tomography pulmonary angiography (CTPA). Results of the Guthrie tests were systematically collected for newborns of all women who required CTPA as part of the diagnostic strategy. A TSH level above 15 U/ml was used to define hypothyroidism.
RESULTS
Out of the 166 women included in the Swiss participating centers, 149 underwent a CTPA including 14 with twin pregnancies. Eight women suffered a pregnancy loss and results of the Guthrie could not be retrieved for 4 newborns. All TSH levels were reported as being below 15 U/ml. The incidence of neonatal hypothyroidism was 0/151 (0.0%, 95% CI: 0.0-2.5%).
CONCLUSIONS
We did not identify any case of neonatal hypothyroidism in our cohort of 149 pregnant women investigated for suspected PE using a CTPA. Along with previous literature data, this provides further reassuring data regarding the use of CTPA in this indication.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine 04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine |
UniBE Contributor: |
Aujesky, Drahomir |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1538-7836 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
12 Aug 2022 09:53 |
Last Modified: |
13 Aug 2023 00:25 |
Publisher DOI: |
10.1111/jth.15843 |
PubMed ID: |
35950611 |
Uncontrolled Keywords: |
Guthrie test diagnosis hypothyroidism pregnancy pulmonary embolism |
BORIS DOI: |
10.48350/171906 |
URI: |
https://boris.unibe.ch/id/eprint/171906 |
Actions (login required)
 |
Edit item |