Zhang, Qi; Lin, Jinran; Zhang, Zhenghua; Han, Ling; Huang, Qiong; Zhu, Jie; Wang, Bing; Fang, Xu; Zheng, Zhizhong; Yawalkar, Nikhil; Liang, Jun; Yan, Kexiang (2022). MTHFR Polymorphism and Folic Acid Supplementation Influence Serum Homocysteine Levels in Psoriatic Patients Treated with Methotrexate. Journal of clinical medicine, 11(15) MDPI 10.3390/jcm11154580
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BACKGROUND
Hyperhomocysteinemia has been reported in psoriasis. We investigated the effect of methylenetetrahydrofolate reductase (MTHFR), polymorphism and folic acid supplementation on serum homocysteine levels in psoriasis.
METHODS
Serum homocysteine levels were detected at baseline and at week 12 in 201 patients who were genotyped with MTHFR rs1801133 without and 93 psoriatic patients with folate supplement.
RESULTS
TT genotype carriers of MTHFR rs1801133 had significantly higher serum homocysteine levels at baseline and at week 12, a better PASI 75 response rate at week 8, and a higher PASI 90 response rate at week 12 than the CT and CC genotype carriers. Multiple regression analysis demonstrated that serum homocysteine concentration at baseline was significantly associated with sex, weight, PASI score at baseline, and the rs1801133 genotype. The significant upregulation of serum homocysteine levels after treatment with methotrexate (MTX) was only observed in male CT and CC genotype carriers and female CC genotype carriers. In contrast, folic acid supplementation significantly decreased serum homocysteine levels after MTX treatment but only in male psoriatic patients.
CONCLUSIONS
The effect of MTX on serum homocysteine levels was associated with the polymorphism of MTHFR rs1801133 and sex. Folic acid supplementation only decreased serum homocysteine levels in male psoriatic patients.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Yawalkar, Nikhil |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2077-0383 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
16 Aug 2022 15:35 |
Last Modified: |
05 Dec 2022 16:22 |
Publisher DOI: |
10.3390/jcm11154580 |
PubMed ID: |
35956194 |
Uncontrolled Keywords: |
homocysteine methotrexate methylenetetrahydrofolate reductase psoriasis rs1801133 |
BORIS DOI: |
10.48350/171952 |
URI: |
https://boris.unibe.ch/id/eprint/171952 |
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