Pfender, Nikolai; Rosner, Jan; Zipser, Carl Moritz; Friedl, Susanne; Vallotton, Kevin; Sutter, Reto; Klarhoefer, Markus; Schubert, Martin; Betz, Michael; Spirig, José Miguel; Seif, Maryam; Hubli, Michèle; Freund, Patrick; Farshad, Mazda; Curt, Armin; Hupp, Markus (2022). Comparison of axial and sagittal spinal cord motion measurements in degenerative cervical myelopathy. Journal of neuroimaging, 32(6), pp. 1121-1133. Wiley 10.1111/jon.13035
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Journal_of_Neuroimaging_-_2022_-_Pfender_-_Comparison_of_axial_and_sagittal_spinal_cord_motion_measurements_in_degenerative.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (3MB) | Preview |
BACKGROUND AND PURPOSE
The timing of decision-making for a surgical intervention in patients with mild degenerative cervical myelopathy (DCM) is challenging. Spinal cord motion phase contrast MRI (PC-MRI) measurements can reveal the extent of dynamic mechanical strain on the spinal cord to potentially identify high-risk patients. This study aims to determine the comparability of axial and sagittal PC-MRI measurements of spinal cord motion with the prospect of improving the clinical workup.
METHODS
Sixty-four DCM patients underwent a PC-MRI scan assessing spinal cord motion. The agreement of axial and sagittal measurements was determined by means of intraclass correlation coefficients (ICCs) and Bland-Altman analyses.
RESULTS
The comparability of axial and sagittal PC-MRI measurements was good to excellent at all cervical levels (ICCs motion amplitude: .810-.940; p < .001). Significant differences between axial and sagittal amplitude values could be found at segments C3 and C4, while its magnitude was low (C3: 0.07 ± 0.19 cm/second; C4: -0.12 ± 0.30 cm/second). Bland-Altman analysis showed a good agreement between axial and sagittal PC-MRI scans (coefficients of repeatability: minimum -0.23 cm/second at C2; maximum -0.58 cm/second at C4). Subgroup analysis regarding anatomic conditions (stenotic vs. nonstenotic segments) and different velocity encoding (2 vs. 3 cm/second) showed comparable results.
CONCLUSIONS
This study demonstrates good comparability between axial and sagittal spinal cord motion measurements in DCM patients. To this end, axial and sagittal PC-MRI are both accurate and sensitive in detecting pathologic cord motion. Therefore, such measures could identify high-risk patients and improve clinical decision-making (ie, timing of decompression).
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Rosner, Jan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1051-2284 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
17 Aug 2022 14:40 |
Last Modified: |
05 Dec 2022 16:22 |
Publisher DOI: |
10.1111/jon.13035 |
PubMed ID: |
35962464 |
Uncontrolled Keywords: |
cervical stenosis degenerative cervical myelopathy phase contrast MRI spinal cord compression spinal cord motion spinal cord oscillation |
BORIS DOI: |
10.48350/171981 |
URI: |
https://boris.unibe.ch/id/eprint/171981 |
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