Kappel, Sven; Peinelt, Christine (2022). Targeting CRAC channels in inflammatory bowel disease. EMBO molecular medicine, 14(9), e16489. EMBO Press 10.15252/emmm.202216489
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EMBO_Mol_Med_-_2022_-_Kappel_-_Targeting_CRAC_channels_in_inflammatory_bowel_disease.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (359kB) | Preview |
Inflammatory bowel disease (IBD) is a collective term for inflammatory diseases of the human gastrointestinal (GI) tract that are characterized by perturbations in the intestinal immune responses. In their study, Letizia et al (2022) found an enrichment of CD4+ effector T cells, interferon gamma (IFNγ) producing CD8+ T cells, regulatory T cells, and innate lymphoid cells (ILC) in the lamina propria (LP) of IBD patients. In these cells, pharmacological inhibition of store-operated calcium entry (SOCE) reduced cytokine production. In addition, in a murine IBD model, systemic SOCE inhibition reduced IBD severity and weight loss.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Kappel, Sven, Peinelt, Christine |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1757-4684 |
Publisher: |
EMBO Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
17 Aug 2022 08:55 |
Last Modified: |
05 Dec 2022 16:22 |
Publisher DOI: |
10.15252/emmm.202216489 |
PubMed ID: |
35969215 |
BORIS DOI: |
10.48350/172038 |
URI: |
https://boris.unibe.ch/id/eprint/172038 |
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