The Influence of Different Metal-Chelators on the Biological Profil of Nanoparticles for Gallium-68 Based Molecular Imaging

Ng, Quinn Kwan-Tai; Segura, Tatiana; Ben-Shlomo, Anat; Krause, Thomas; Mindt, Thomas L; Walter, Martin A (2012). The Influence of Different Metal-Chelators on the Biological Profil of Nanoparticles for Gallium-68 Based Molecular Imaging. Journal of nano research JNanoR, 20(1), pp. 21-31. Zürich: Trans Tech Publ. 10.4028/www.scientific.net/JNanoR.20.21

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The use of metal chelators is becoming increasingly important in the development of new tracers for molecular imaging. With the rise of the field of nanotechnology, the fusion of both technologies has shown great potential for clinical applications. The pharmacokinetcs of nanoparticles can be monitored via positron emission tomography (PET) after surface modification and radiolabeling with positron emitting radionuclides. Different metal ion chelators can be used to facilitate labeling of the radionuclides and as a prerequisite, optimized radiolabeling procedure is necessary to prevent nanoparticle aggregation and degradation. However, the effects of chelator modification on nanoparticle pharmacokinetic properties have not been well studied and currently no studies to date have compared the biological effects of the use of different chelators in the surface modification of nanoparticles.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Ng, Quinn Kwan-Tai; Krause, Thomas Michael and Walter, Martin Alexander

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1662-5250

Publisher:

Trans Tech Publ.

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:42

Last Modified:

14 Mar 2014 12:14

Publisher DOI:

10.4028/www.scientific.net/JNanoR.20.21

Web of Science ID:

000313760400003

URI:

https://boris.unibe.ch/id/eprint/17210 (FactScience: 224949)

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