Controversy Over Liver Transplantation or Resection for Neuroendocrine Liver Metastasis: Tumor Biology Cuts the Deal.

Eshmuminov, Dilmurodjon; Studer, Debora J; Lopez Lopez, Victor; Schneider, Marcel André; Lerut, Jan; Lo, Mary; Sher, Linda; Musholt, Thomas Johannes; Lozan, Oana; Bouzakri, Nabila; Sposito, Carlo; Miceli, Rosalba; Barat, Shoma; Morris, David; Oehler, Helga; Schreckenbach, Teresa; Husen, Peri; Rosen, Charles B; Gores, Gregory J; Masui, Toshihiko; ... (2023). Controversy Over Liver Transplantation or Resection for Neuroendocrine Liver Metastasis: Tumor Biology Cuts the Deal. Annals of surgery, 277(5), e1063-e1071. Wolters Kluwer Health 10.1097/SLA.0000000000005663

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BACKGROUND

In patients with neuroendocrine liver metastasis (NELM), liver transplantation (LT) is an alternative to liver resection (LR), although the choice of therapy remains controversial. In this multicenter study we aim to provide novel insight in this dispute.

METHODS

Following a systematic literature search, 15 large international centers were contacted to provide comprehensive data on their patients after LR or LT for NELM. Survival analyses were performed with the Kaplan-Meier method, while multivariable Cox regression served to identify factors influencing survival after either transplantation or resection. Inverse probability weighting (IPW) and propensity score matching was used for analyses with balanced and equalized baseline characteristics.

RESULTS

Overall, 455 patients were analyzed, including 230 after LR and 225 after LT, with a median follow-up of 97 (95% CI 85-110) months. Multivariable analysis revealed G3 grading as a negative prognostic factor for LR (HR 2.22, 95%CI 1.04-4.77, P=0.040), while G2 grading (HR 2.52, 95%CI 1.15-5.52, P=0.021) and LT outside Milan criteria (HR 2.40, 95%CI 1.16-4.92, P=0.018) were negative prognostic factors in transplanted patients. IP-weighted multivariate analyses revealed a distinct survival benefit after LT. Matched patients presented a median overall survival (OS) of 197 months (95%CI 143- not reached) and a 73% 5-year OS after LT, and 119 months (95%CI 74-133) and a 52.8% 5-year OS after LR (HR 0.59, 95% CI 0.3- 0.9, P=0.022). However, the survival benefit after LT was lost if patients were transplanted outside Milan criteria.

CONCLUSION

This multicentric study in patients with NELM demonstrates a survival benefit of LT over LR. This benefit depends on adherence to selection criteria, in particular low-grade tumor biology and Milan criteria, and must be balanced against potential risks of LT.

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