Multidimensional phenotyping of the post-COVID-19 syndrome: A Swiss survey study.

Diem, Lara; Schwarzwald, Anina; Friedli, Christoph; Hammer, Helly; Gomes-Fregolente, Livia; Warncke, Jan; Weber, Lea; Kamber, Nicole; Chan, Andrew; Bassetti, Claudio; Salmen, Anke; Hoepner, Robert (2022). Multidimensional phenotyping of the post-COVID-19 syndrome: A Swiss survey study. CNS neuroscience & therapeutics, 28(12), pp. 1953-1963. Wiley 10.1111/cns.13938

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INTRODUCTION

Post-COVID-19 syndrome affects approximately 10-25% of people after a COVID-19 infection, irrespective of initial COVID-19 severity. The aim of this project was to assess the clinical characteristics, course, and prognosis of post-COVID-19 syndrome using a systematic multidimensional approach.

PATIENTS AND METHODS

An online survey of people with suspected and confirmed COVID-19 and post-COVID-19 syndrome, distributed via Swiss COVID-19 support groups, social media, and our post-COVID-19 consultation, was performed. A total of 8 post-infectious domains were assessed with 120 questions. Data were collected from October 15 to December 12, 2021, and 309 participants were included. Analysis of clinical phenomenology of post-COVID-19 syndrome was performed using comparative statistics.

RESULTS

The three most prevalent post-COVID-19 symptoms in our survey cohort were fatigue (288/309, 93.2%), pain including headache (218/309, 70.6%), and sleep-wake disturbances (mainly insomnia and excessive daytime sleepiness, 145/309, 46.9%). Post-COVID-19 syndrome had an impact on work ability, as more than half of the respondents (168/268, 62.7%) reported an inability to work, which lasted on average 26.6 weeks (95% CI 23.5-29.6, range 1-94, n = 168). Quality of life measured by WHO-5 Well-being Index was overall low in respondents with post-COVID-19 syndrome (mean, 95% CI 9.1 [8.5-9.8], range 1-25, n = 239).

CONCLUSION

Fatigue, pain, and sleep-wake disturbances were the main symptoms of the post-COVID-19 syndrome in our cohort and had an impact on the quality of life and ability to work in a majority of patients. However, survey respondents reported a significant reduction in symptoms over 12 months. Post-COVID-19 syndrome remains a significant challenge. Further studies to characterize this syndrome and to explore therapeutic options are therefore urgently needed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Diem, Lara, Schwarzwald, Anina Eliane, Friedli, Christoph Daniel, Hammer, Helly Noemi, Gomes, Livia, Warncke, Jan, Weber, Lea, Kamber, Nicole, Chan, Andrew Hao-Kuang, Bassetti, Claudio L.A., Salmen, Anke, Hoepner, Robert

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1755-5949

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

18 Aug 2022 10:37

Last Modified:

05 Dec 2022 16:22

Publisher DOI:

10.1111/cns.13938

PubMed ID:

35975339

Uncontrolled Keywords:

SARS-CoV-2 coronavirus long-term symptoms neuropsychiatric symptoms post-infectious viral infection

BORIS DOI:

10.48350/172158

URI:

https://boris.unibe.ch/id/eprint/172158

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