Roux-en-Y gastric bypass with a long versus a short biliopancreatic limb improves weight loss and glycemic control in obese mice.

Schneider, Romano; Kraljević, Marko; Peterli, Ralph; Rohm, Theresa V; Bosch, Angela J T; Low, Andy J Y; Keller, Lena; AlAsfoor, Shefaa; Häfliger, Simon; Yilmaz, Bahtiyar; Peterson, Caspar J; Lazaridis, Ioannis I; Vonaesch, Pascale; Delko, Tarik; Cavelti-Weder, Claudia (2022). Roux-en-Y gastric bypass with a long versus a short biliopancreatic limb improves weight loss and glycemic control in obese mice. Surgery for obesity and related diseases, 18(11), pp. 1286-1297. Elsevier 10.1016/j.soard.2022.06.286

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BACKGROUND

Roux-en-Y gastric bypass (RYGB) results in long-term weight loss and reduced obesity related co-morbidities. However, little is known about how the lengths of the biliopancreatic limb (BPL), the alimentary limb (AL), and the common limb (CL) affect weight loss and glucose metabolism.

OBJECTIVES

Our aim was to establish a RYGB obese mouse model with defined proportions of the AL and BPL and a constant CL to assess the effects on weight loss,glucose metabolism, and obesity-related co-morbidities.

SETTING

In vivo mouse study.

METHODS

Six-week-old male C57BL/6J mice fed with a high-fat diet (HFD) underwent bariatric surgery with defined BPL lengths: a very long, long, and short BPL (35%, 25%, and 15% of total bowel length), or sham surgery. The length of the AL was adjusted to achieve the same CL length. Mice were analyzed for weight loss, glycemic control, and obesity-related co-morbidities.

RESULTS

Mice undergoing RYGB surgery with a very long BPL had excessive weight loss and mortality and were therefore not further analyzed. Mice with a long BPL showed a significantly increased total weight loss when compared with mice with a short BPL. In addition, a long BPL improved glucose tolerance, particularly early after surgery. A long BPL was also associated with lower triglyceride levels. Resolution of hepatic steatosis and adipose tissue inflammation was, however, not statistically significant. Of note, bariatric surgery dramatically changed gut microbiota, regardless of limb length.

CONCLUSION

In obese mice, a long BPL results in enhanced weight loss and improved glucose tolerance. These findings could potentially be translated to humans by tailoring the BPL length according to body weight, obesity-related co-morbidities, and total bowel length of an individual patient.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Yilmaz, Bahtiyar (A)

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1878-7533

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

24 Aug 2022 14:05

Last Modified:

05 Dec 2022 16:23

Publisher DOI:

10.1016/j.soard.2022.06.286

PubMed ID:

35995662

Uncontrolled Keywords:

Gastric bypass Gut physiology Morbid obesity RYGB animal model Small bowel

BORIS DOI:

10.48350/172341

URI:

https://boris.unibe.ch/id/eprint/172341

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