Stereotactic radiosurgery and radiotherapy for resected brain metastases: current pattern of care in the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Association for Radiation Oncology (DEGRO).

Rogers, S; Baumert, B; Blanck, O; Böhmer, D; Boström, J; Engenhart-Cabillic, R; Ermis, E; Exner, S; Guckenberger, M; Habermehl, D; Hemmatazad, H; Henke, G; Lohaus, F; Lux, S; Mai, S; Minasch, D; Rezazadeh, A; Steffal, C; Temming, S; Wittig, A; ... (2022). Stereotactic radiosurgery and radiotherapy for resected brain metastases: current pattern of care in the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Association for Radiation Oncology (DEGRO). Strahlentherapie und Onkologie, 198(10), pp. 919-925. Springer 10.1007/s00066-022-01991-6

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PURPOSE

Preoperative stereotactic radiosurgery (SRS) of brain metastases may achieve similar local control and better leptomeningeal control rates than postoperative fractionated stereotactic radiotherapy (FSRT) in patients treated with elective metastasectomy. To plan a multicentre trial of preoperative SRS compared with postoperative FSRT, a survey of experts was conducted to determine current practice.

METHODS

A survey with 15 questions was distributed to the DEGRO Radiosurgery and Stereotactic Radiotherapy Working Group. Participants were asked under what circumstances they offered SRS, FSRT, partial and/or whole brain radiotherapy before or after resection of a brain metastasis, as well as the feasibility of preoperative stereotactic radiosurgery and neurosurgical resection within 6 days.

RESULTS

Of 25 participants from 24 centres, 22 completed 100% of the questions. 24 respondents were radiation oncologists and 1 was a neurosurgeon. All 24 centres have one or more dedicated radiosurgery platform and all offer postoperative FSRT. Preoperative SRS is offered by 4/24 (16.7%) centres, and 9/24 (37.5%) sometimes recommend single-fraction postoperative SRS. Partial brain irradiation is offered by 8/24 (33.3%) centres and 12/24 (50%) occasionally recommend whole-brain irradiation. Two centres are participating in clinical trials of preoperative SRS. SRS techniques and fractionation varied between centres.

CONCLUSION

All responding centres currently offer postoperative FSRT after brain metastasectomy. Approximately one third offer single-fraction postoperative SRS and four already perform preoperative SRS. With regard to potential co-investigators, 18 were identified for the PREOP‑2 multicentre trial, which will randomise between preoperative SRS and postoperative FSRT.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Ermis, Ekin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1439-099X

Publisher:

Springer

Language:

English

Submitter:

Pubmed Import

Date Deposited:

26 Aug 2022 09:53

Last Modified:

05 Dec 2022 16:23

Publisher DOI:

10.1007/s00066-022-01991-6

Related URLs:

PubMed ID:

36006436

Uncontrolled Keywords:

Central nervous system Leptomeningeal SRS Secondary Tumour

BORIS DOI:

10.48350/172380

URI:

https://boris.unibe.ch/id/eprint/172380

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