Corpataux, Noé; Hochholzer, Willibald; Valina, Christian Marc; Ferenc, Miroslaw; Löffelhardt, Nikolaus; Westermann, Dirk; Neumann, Franz-Josef; Nührenberg, Thomas Georg (2022). Serum lipoprotein(a) and 3-year outcomes in patients undergoing percutaneous coronary intervention. Current problems in cardiology, 47(12), p. 101362. Elsevier 10.1016/j.cpcardiol.2022.101362
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BACKGROUND AND AIMS
We aimed at addressing the association between serum lipoprotein (a) levels and clinical outcomes of consecutive patients undergoing PCI.
METHODS
We used consecutive patients undergoing PCI at the Heart Center University of Freiburg, Bad Krozingen in Germany between January 2005 and November 2013. A total of 6679 patients [men (n = 5391) and women (n = 1288)] mean aged 67.5 (± 11.1) years were assessed at baseline and prospectively followed for 3 years. Lp(a) measurement were performed at hospital admission as a routine laboratory parameter.
RESULTS
Approximately 30% of PCI patients show an elevated Lp(a) value of more than 50mg/dL. In total, 736 Patients died during the follow-up, thereof 189 (11.3%) in the first quartile, 186 (10.7%) in the second quartile, 183 (11.5%) in the third quartile and 178 (10.7%) in the last quartile (p value 0.843 from LogRank test). The MACE rate showed consistent results with 409 (24.4%), 385 (22.1%), 395 (24.7%) and 419 (25.3%) in the different respective quartiles (p value 0.125 from LogRank test).
CONCLUSION
In this large non-selected cohort of patients undergoing PCI followed by moderate intensity statin therapy, higher Lp(a) levels were not associated with worse clinical outcomes during a follow-up of 3 years.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Corpataux, Noé Emile |
ISSN: |
1535-6280 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
29 Aug 2022 15:19 |
Last Modified: |
05 Dec 2022 16:23 |
Publisher DOI: |
10.1016/j.cpcardiol.2022.101362 |
PubMed ID: |
36028053 |
Uncontrolled Keywords: |
Lipoprotein (a) PCI atherosclerosis cardiovascular disease coronary artery disease |
BORIS DOI: |
10.48350/172399 |
URI: |
https://boris.unibe.ch/id/eprint/172399 |
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