Riggers, Denise S; Gurtner, Corinne; Protschka, Martina; Böttcher, Denny; von Bomhard, Wolf; Alber, Gottfried; Winter, Karsten; Steiner, Joerg M; Heilmann, Romy M (2022). Intestinal S100/Calgranulin Expression in Cats with Chronic Inflammatory Enteropathy and Intestinal Lymphoma. Animals, 12(16) MDPI 10.3390/ani12162044
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Diagnosing chronic inflammatory enteropathies (CIE) in cats and differentiation from intestinal lymphoma (IL) using currently available diagnostics is challenging. Intestinally expressed S100/calgranulins, measured in fecal samples, appear to be useful non-invasive biomarkers for canine CIE but have not been evaluated in cats. We hypothesized S100/calgranulins to play a role in the pathogenesis of feline chronic enteropathies (FCE) and to correlate with clinical and/or histologic disease severity. This retrospective case-control study included patient data and gastrointestinal (GI) tissues from 16 cats with CIE, 8 cats with IL, and 16 controls with no clinical signs of GI disease. GI tissue biopsies were immunohistochemically stained using polyclonal α-S100A8/A9 and α-S100A12 antibodies. S100A8/A9+ and S100A12+ cells were detected in all GI segments, with few significant differences between CIE, IL, and controls and no difference between diseased groups. Segmental inflammatory lesions were moderately to strongly correlated with increased S100/calgranulin-positive cell counts. Clinical disease severity correlated with S100A12+ cell counts in cats with IL (ρ = 0.69, p = 0.042) and more severe diarrhea with colonic lamina propria S100A12+ cells with CIE (ρ = 0.78, p = 0.021) and duodenal S100A8/A9+ cells with IL (ρ = 0.71, p = 0.032). These findings suggest a role of the S100/calgranulins in the pathogenesis of the spectrum of FCE, including CIE and IL.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) |
UniBE Contributor: |
Gurtner, Corinne |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
2076-2615 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
29 Aug 2022 14:11 |
Last Modified: |
05 Dec 2022 16:23 |
Publisher DOI: |
10.3390/ani12162044 |
PubMed ID: |
36009635 |
Uncontrolled Keywords: |
S100A12 S100A8/A9 calgranulin C calgranulins calprotectin chronic enteropathy chronic inflammatory enteropathy feline food-responsive enteropathy intestinal lymphoma small-cell lymphoma |
BORIS DOI: |
10.48350/172425 |
URI: |
https://boris.unibe.ch/id/eprint/172425 |
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