Global, Regional, and National Trends of Chagas Disease from 1990 to 2019: Comprehensive Analysis of the Global Burden of Disease Study.

Gómez-Ochoa, Sergio Alejandro; Rojas, Lyda Z; Echeverría, Luis E; Muka, Taulant; Franco, Oscar H (2022). Global, Regional, and National Trends of Chagas Disease from 1990 to 2019: Comprehensive Analysis of the Global Burden of Disease Study. Global heart, 17(1), p. 59. Ubiquity Press 10.5334/gh.1150

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Background

Chagas disease (CD) is a neglected tropical disease, endemic in Latin America, but due to migration and environmental changes it has become a global public health issue.

Objectives

To assess the global prevalence and disability-adjusted life years due to CD using findings from the Global Burden of Disease Study 2019.

Methods

The Global Burden of Disease data was obtained from the Global Burden of Disease Collaborative Network; results were provided by the Institute for Health Metrics and Evaluation. The prevalence and disability-adjusted life-years (DALYs) were described at a global, regional, and national level, including data from 1990 to 2019.

Results

Globally, CD prevalence decreased by 11.3% during the study period, from 7,292,889 cases estimated in 1990 to 6,469,283 in 2019. Moreover, the global DALY rate of CD decreased by 23.7% during the evaluated period, from 360,872 in 1990 to 275,377 in 2019. In addition, significant differences in the burden by sex, being men the most affected, age, with the elderly having the highest burden of the disease, and sociodemographic index (SDI), with countries with the lowest SDI values having the highest prevalence of the disease, were observed. Finally, the prevalence trends have followed different patterns according to the region, with a sustained decrease in Latin America, compared to an increasing trend in North America and Europe until 2010.

Conclusion

The global burden of CD has changed in recent decades, with a sustained decline in the number of cases. Although the majority of cases remain concentrated in Latin America, the increase observed in countries in North America and Europe highlights the importance of screening at-risk populations and raising awareness of this neglected tropical disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Muka, Taulant, Franco Duran, Oscar Horacio

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

2211-8160

Publisher:

Ubiquity Press

Language:

English

Submitter:

Pubmed Import

Date Deposited:

05 Sep 2022 15:22

Last Modified:

05 Dec 2022 16:23

Publisher DOI:

10.5334/gh.1150

PubMed ID:

36051318

Uncontrolled Keywords:

Chagas Disease Prevalence Public Health

BORIS DOI:

10.48350/172654

URI:

https://boris.unibe.ch/id/eprint/172654

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