Beyond keratinocyte differentiation: emerging new biology of small proline-rich proteins.

Zabini, Adam; Zimmer, Yitzhak; Medová, Michaela (2023). Beyond keratinocyte differentiation: emerging new biology of small proline-rich proteins. Trends in cell biology, 33(1), pp. 5-8. Elsevier 10.1016/j.tcb.2022.08.002

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Small proline-rich proteins (SPRRPs) are traditionally known for their function in keratinocyte homeostasis. Recent evidence demonstrates their involvement in additional diverse physiological processes ranging from p53 signaling and direct prevention of DNA damage to bactericidal activities. We highlight these novel, intriguing roles of SPRRPs and discuss them in the context of relevant pathological conditions.

Item Type:

 Journal Article (Further Contribution)

Division/Institute:

 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radio-Onkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radio-Onkologie
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

 Zabini, Adam, Zimmer, Yitzhak, Medova, Michaela

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 1879-3088

Publisher:

 Elsevier

Language:

 English

Submitter:

 Pubmed Import

Date Deposited:

 08 Sep 2022 09:15

Last Modified:

 13 Jan 2023 11:18

Publisher DOI:

 10.1016/j.tcb.2022.08.002

PubMed ID:

 36057494

Uncontrolled Keywords:

 DNA damage protection bactericidal activity cornified cell envelope epithelial tissue defense p53 signaling reactive oxygen species small proline-rich proteins

BORIS DOI:

 10.48350/172695

URI:

 https://boris.unibe.ch/id/eprint/172695

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