Klail, Tomas; Kurmann, Christoph; Kaesmacher, Johannes; Mujanovic, Adnan; Piechowiak, Eike I; Dobrocky, Tomas; Pilgram-Pastor, Sara; Scutelnic, Adrian; Heldner, Mirjam R; Gralla, Jan; Mordasini, Pasquale (2023). Safety and Efficacy of Carotid Artery Stenting with the CGuard Double-layer Stent in Acute Ischemic Stroke. Clinical neuroradiology, 33(1), pp. 237-244. Springer-Verlag 10.1007/s00062-022-01209-3
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BACKGROUND
Double-layer stents show promising results in preventing periinterventional and postinterventional embolic events in elective settings of carotid artery stenting (CAS). We report a single-center experience with the CGuard stent in the treatment of acute ischemic stroke (AIS) due to symptomatic internal carotid artery (ICA) stenosis or occlusion with or without intracranial occlusion.
METHODS
We retrospectively analyzed all patients who received a CGuard stent in the setting of AIS at our institution. Neuroimaging and clinical data were analyzed with the following primary endpoints: technical feasibility, acute and delayed stent occlusion or thrombosis, distal embolism, symptomatic intracranial hemorrhage (sICH) and functional outcome at 3 months.
RESULTS
In 33 patients, stenting with the CGuard was performed. Stent deployment was successful in all patients (28 with tandem occlusions, 5 with isolated ICA occlusion). Transient acute in-stent thrombus formation occurred in three patients (9%) without early stent occlusion. Delayed, asymptomatic stent occlusion was seen in 1 patient (3%) after 49 days. Asymptomatic periinterventional distal emboli occurred in 2 patients (6%), 1 patient experienced a transient ischemic attack 79 days after the procedure and 1 patient (3%) developed sICH. Favorable clinical outcome (mRS 0-2) at 3 months was achieved in 12 patients (36%) and the mortality rate was 24%.
CONCLUSION
The CGuard use in emergencies was technically feasible, the safety has to be confirmed by further multicentric studies.
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