Once versus twice daily direct oral anticoagulants in patients with recent stroke and atrial fibrillation.

Polymeris, Alexandros A; Zietz, Annaelle; Schaub, Fabian; Meya, Louisa; Traenka, Christopher; Thilemann, Sebastian; Wagner, Benjamin; Hert, Lisa; Altersberger, Valerian L; Seiffge, David J; Lyrer, Flurina; Dittrich, Tolga; Piot, Ines; Kaufmann, Josefin; Barone, Lea; Dahlheim, Ludvig; Flammer, Sophie; Avramiotis, Nikolaos S; Peters, Nils; De Marchis, Gian Marco; ... (2022). Once versus twice daily direct oral anticoagulants in patients with recent stroke and atrial fibrillation. European stroke journal, 7(3), pp. 221-229. Sage 10.1177/23969873221099477

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Data on the safety and effectiveness of once-daily (QD) versus twice-daily (BID) direct oral anticoagulants (DOAC) in comparison to vitamin K antagonists (VKA) and to one another in patients with atrial fibrillation (AF) and recent stroke are scarce.

Patients and methods

Based on prospectively obtained data from the observational registry Novel-Oral-Anticoagulants-in-Ischemic-Stroke-Patients(NOACISP)-LONGTERM (NCT03826927) from Basel, Switzerland, we compared the occurrence of the primary outcome - the composite of recurrent ischemic stroke, major bleeding, and all-cause death - among consecutive AF patients treated with either VKA, QD DOAC, or BID DOAC following a recent stroke using Cox proportional hazards regression including adjustment for potential confounders.


We analyzed 956 patients (median age 80 years, 46% female), of whom 128 received VKA (13.4%), 264 QD DOAC (27.6%), and 564 BID DOAC (59%). Over a total follow-up of 1596 patient-years, both QD DOAC and BID DOAC showed a lower hazard for the composite outcome compared to VKA (adjusted HR [95% CI] 0.69 [0.48, 1.01] and 0.66 [0.47, 0.91], respectively). Upon direct comparison, the hazard for the composite outcome did not differ between patients treated with QD versus BID DOAC (adjusted HR [95% CI] 0.94 [0.70, 1.26]). Secondary analyses focusing on the individual components of the composite outcome revealed no clear differences in the risk-benefit profile of QD versus BID DOAC.

Discussion and conclusion

The overall benefit of DOAC over VKA seems to apply to both QD and BID DOAC in AF patients with a recent stroke, without clear evidence that one DOAC dosing regimen is more advantageous than the other.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Seiffge, David Julian


600 Technology > 610 Medicine & health








Pubmed Import

Date Deposited:

13 Sep 2022 13:37

Last Modified:

05 Dec 2022 16:24

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Uncontrolled Keywords:

Direct oral anticoagulants atrial fibrillation once-daily regimen stroke twice-daily





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