Lugarà, Rosamaria; Renner, Simone; Wolf, Eckhard; Liesegang, Annette; Bruckmaier, Rupert; Giller, Katrin (2022). Crossbred Sows Fed a Western Diet during Pre-Gestation, Gestation, Lactation, and Post-Lactation Periods Develop Signs of Lean Metabolic Syndrome That Are Partially Attenuated by Spirulina Supplementation. Nutrients, 14(17) MDPI 10.3390/nu14173574
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Excessive dietary intake of fats and sugars ("Western diet", WD) is one of the leading causes of obesity. The consumption of the microalga Arthrospira platensis (spirulina, Sp) is increasing due to its presumed health benefits. Both WD and Sp are also consumed by pregnant and breastfeeding women. This study investigated if gestating and lactating domestic pigs are an appropriate model for WD-induced metabolic disturbances similar to those observed in humans and if Sp supplementation may attenuate any of these adverse effects. Pigs were fed a WD high in fat, sugars, and cholesterol or a control diet. Half of the animals per diet group were supplemented with 20 g Sp per day. The WD did not increase body weight or adipose tissue accumulation but led to metabolic impairments such as higher cholesterol concentration in plasma, lower IGF1 plasma levels, and signs of hepatic damage compared to the control group. Spirulina supplementation could not reduce all the metabolic impairments observed in WD-fed animals. These findings indicate limited suitability of gestating and lactating domestic pigs as a model for WD but a certain potential of low-dose Sp supplementation to partially attenuate negative WD effects.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Physiology 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) |
UniBE Contributor: |
Bruckmaier, Rupert |
Subjects: |
600 Technology > 630 Agriculture |
ISSN: |
2072-6643 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 Sep 2022 13:56 |
Last Modified: |
07 Aug 2024 15:45 |
Publisher DOI: |
10.3390/nu14173574 |
PubMed ID: |
36079836 |
Uncontrolled Keywords: |
dietary fat dietary sugar gene expression insulin-like growth factor liver steatosis microalgae pig model skeletal muscle |
BORIS DOI: |
10.48350/172794 |
URI: |
https://boris.unibe.ch/id/eprint/172794 |
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