Nyakato, Patience; Christ, Benedikt; Anderegg, Nanina; Muhairwe, Josephine; Jefferys, Laura; van Dijk, Janneke; Vinikoor, Michael J; van Lettow, Monique; Chimbetete, Cleophas; Phiri, Sam J; Egger, Matthias; Ballif, Marie; Yiannoutsos, Constantin T; Schomaker, Michael; Kassanjee, Reshma; Davies, Mary-Ann; Cornell, Morna (2022). High unreported mortality in children and youth (<25 years) living with HIV who were lost to care from antiretroviral therapy programs in Southern Africa: results from a multi-country tracing study. Journal of acquired immune deficiency syndromes JAIDS, 91(5), pp. 429-433. Lippincott Williams & Wilkins 10.1097/QAI.0000000000003090
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BACKGROUND
Antiretroviral therapy (ART) program mortality maybe underestimated if deceased patients are misclassified as lost.
METHODS
We used two-stage inverse probability weighting to account for probability of being: sampled for tracing and found by the tracer.
RESULTS
Among 680 children and youth aged <25 years on ART who were lost and traced in Southern Africa between October 2017-November 2019, estimated mortality was high at 9.1% (62/680). After adjusting for measured covariates and within-site clustering, mortality remained lower for young adults aged 20-24 years compared to infants aged <2years (adjusted Hazard ratio (aHR): 0.40 (95% confidence interval (CI): 0.31, 0.51)).
CONCLUSIONS
Our study confirms high unreported mortality in children and youth who are lost and the need for tracing to assess vital status among those who are lost to accurately report on program mortality.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Christ, Martin Benedikt, Anderegg, Nanina Tamar, Egger, Matthias, Ballif, Marie |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0894-9255 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
14 Sep 2022 14:05 |
Last Modified: |
05 Dec 2022 16:24 |
Publisher DOI: |
10.1097/QAI.0000000000003090 |
PubMed ID: |
36099024 |
BORIS DOI: |
10.48350/172865 |
URI: |
https://boris.unibe.ch/id/eprint/172865 |
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