Lam, Ka-Hoo; van Munster, Caspar E P; D'Souza, Marcus; Steinheimer, Saskia; Kamm, Christian P; Burggraaff, Jessica; Johnson, Matthew; Zaykov, Yordan; Dorn, Jonas; Dahlke, Frank; Kappos, Ludwig; Killestein, Joep; Uitdehaag, Bernard (2022). Improving Detection of Change in Motor Functioning in Multiple Sclerosis Using Video-Assisted Composite Measures. International journal of MS care, 24(5), pp. 230-234. Consortium of Multiple Sclerosis Centers 10.7224/1537-2073.2021-044
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BACKGROUND
Assessing motor functioning is important to monitor the disease course of multiple sclerosis (MS). Video-assisted rating of classic neurologic tests and activities of daily living may improve the detection of changes in motor functioning. We investigated the value of using video-assisted composite measures for the detection of changes in mobility and upper extremity function (UEF).
METHODS
Forty-three patients with MS were recorded performing motor function tests before and during treatment with fampridine. Patients were classified as improved or not improved on mobility composite (MOB-COM) and UEF composite (UEF-COM) measures based on neurologists' ratings of the tests. The proportional agreements between the composite measures and the conventional measures-the Timed 25-Foot Walk test (T25FW) and the Nine-Hole Peg Test (NHPT)-were determined and compared with patient-perceived improvement, which was determined using patient-reported ratings of changes in mobility and UEF.
RESULTS
Agreement between MOB-COM and T25FW was 79.5%, and agreement between UEF-COM and NHPT was 82.1%. Twenty-six of 39 patients (66.7%) reported mobility improvement; 6 of these reports were confirmed by both T25FW and MOB-COM, 4 were confirmed by T25FW only, and 2 were confirmed by MOB-COM only. For UEF, 13 of 39 patients (33.3%) reported improvement; 3 of these were confirmed by the NHPT and 3 were confirmed by the UEF-COM.
CONCLUSIONS
Compared with the conventional NHPT measure, the video-assisted composite measure of UEF detected additional patient-perceived improvement. This was less evident for mobility measures. Video-assisted composite measures may enhance the detection of treatment effects in MS clinical practice and trials.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Steinheimer, Saskia Marie, Kamm, Christian Philipp |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1537-2073 |
Publisher: |
Consortium of Multiple Sclerosis Centers |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
15 Sep 2022 07:43 |
Last Modified: |
05 Dec 2022 16:24 |
Publisher DOI: |
10.7224/1537-2073.2021-044 |
PubMed ID: |
36090237 |
Uncontrolled Keywords: |
clinical assessment multiple sclerosis rehabilitation upper extremity function video-assisted |
BORIS DOI: |
10.48350/172887 |
URI: |
https://boris.unibe.ch/id/eprint/172887 |
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