Müller, Christoph; Kägi, David; Aebischer, Toni; Odermatt, Bernhard; Held, Werner; Podack, Eckhard R; Zinkernagel, Rolf M; Hengartner, Hans (1989). Detection of perforin and granzyme A mRNA in infiltrating cells during infection of mice with lymphocytic choriomeningitis virus. European journal of immunology, 19(7), pp. 1253-1259. Wiley-VCH 10.1002/eji.1830190716
Full text not available from this repository. (Request a copy)The analysis of gene expression in cytotoxic T cells by in situ hybridization of serial liver and brain sections from mice infected with lymphocytic choriomeningitis virus (LCMV) and immunostaining with T cell marker- and virus-specific antibodies revealed a close histological association of infiltrating lymphocytes expressing the perforin and granzyme A genes with virally infected cells. Maximal frequency of perforin and granzyme A mRNA-containing cells on liver sections preceded by about 2 days maximal LCMV-specific cytotoxicity of the lymphoid liver infiltrating cells. These results are most consistent with an involvement of perforin and granzyme A in cell-mediated cytotoxicity in vivo.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Müller, Christoph (C) |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0014-2980 |
Publisher: |
Wiley-VCH |
Language: |
English |
Submitter: |
Christoph Müller |
Date Deposited: |
20 Sep 2022 12:15 |
Last Modified: |
29 Mar 2023 23:38 |
Publisher DOI: |
10.1002/eji.1830190716 |
PubMed ID: |
2668013 |
URI: |
https://boris.unibe.ch/id/eprint/172927 |
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