Supramolecular Self-Assembly of Pyrene-DNA Conjugates into Vesicles

Thiede, Jan; Langenegger, Simon M.; Häner, Robert (8 September 2022). Supramolecular Self-Assembly of Pyrene-DNA Conjugates into Vesicles (Unpublished). In: Swiss Chemical Society Fall Meeting 2022. Univeristry of Zürich. 08.09.2022.

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Recently the supramolecular assembly of DNA conjugates has caught attention in supramolecular chemistry. DNA offer some unique characteristics allowing the design of complex nanostructures. The DNA framework allows the defined spatial arrangement of modifications. In previous work DNA was modified with phenanthrene sticky ends forming vesicular supramolecular assemblies with light-harvesting properties.[1] Interestingly, E-tetraphenylethylenes modifications at the 3’-ends of DNA led to aggregation-induced emission (AIE) active assemblies.[2] In this work, we modified a DNA strand at the 3’- and 5’-end with 2,7-pyrene (Figure 1A). AFM measurements of the 2,7-pyrene-DNA conjugates revealed their self-assembly into vesicles (Figure 1B). In addition to AFM studies, fluorescence and UV-vis spectroscopy measurements will be presented and discussed.

Item Type:

Conference or Workshop Item (Poster)

Division/Institute:

08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Thiede, Jan; Langenegger, Simon Matthias and Häner, Robert

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

Language:

English

Submitter:

Jan Thiede

Date Deposited:

19 Sep 2022 08:42

Last Modified:

19 Sep 2022 08:42

Uncontrolled Keywords:

Supramolecular Assembly

BORIS DOI:

10.48350/172985

URI:

https://boris.unibe.ch/id/eprint/172985

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