Pyrene-DNA Conjugates: Influence of sticky Ends on the Supramolecular Self-Assembly

Thiede, Jan; Langenegger, Simon M.; Häner, Robert (15 September 2022). Pyrene-DNA Conjugates: Influence of sticky Ends on the Supramolecular Self-Assembly (Unpublished). In: Swiss Summer School 2022 on Chemical Biology. Les Diablerets, Switzerland. 11-15.09.2022.

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The supramolecular assembly of DNA conjugates has caught attention in supramolecular chemistry. DNA bears some unique features enabling the design of complex nanostructures. The DNA framework offers a defined spatial arrangement of modifications. In preceding work DNA was modified with phenanthrene at the 3’-ends of DNA forming vesicular supramolecular assemblies with unique light-harvesting properties.[1] Interestingly, the modification of DNA with E-tetraphenylethylenes sticky ends led to aggregation-induced emission (AIE) active assemblies.[2] In this work, we modified a DNA strand at the 3’- and 5’-end with 1,6-pyrene (Figure 1A). We varied the length of the sticky ends to compare their self-assembly properties (1, 2, and 3 pyrene units on either side). For example, AFM measurements of the 1,6-pyrene-DNA conjugates with a total of 6 pyrene units revealed their self-assembly into vesicles (Figure 1B). In addition to AFM studies, fluorescence and UV-vis spectroscopy measurements will be presented and discussed.

Item Type:

Conference or Workshop Item (Poster)


08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)

UniBE Contributor:

Thiede, Jan, Langenegger, Simon Matthias, Häner, Robert


500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry




Jan Thiede

Date Deposited:

19 Sep 2022 08:44

Last Modified:

19 May 2023 22:28




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