Characteristics of In Vivo Animal Models of Delayed Cerebral Vasospasm

Marbacher, Serge; Fandino, Javier; Kitchen, Neil (2011). Characteristics of In Vivo Animal Models of Delayed Cerebral Vasospasm. In: Feng, Hua; Mao, Ying; Zhang, John H. (eds.) Early Brain Injury or Cerebral Vasospasm. Acta Neurochirurgica Supplement: Vol. 110/1 (pp. 173-175). Vienna: Springer 10.1007/978-3-7091-0353-1_30

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Animal models provide a basis for clarifying the complex pathogenesis of delayed cerebral vasospasm (DVCS) and for screening of potential therapeutic approaches. The aim of this work was to identify and analyze the most consistent and feasible models and their characteristics for each animal. An online search of the MEDLINE PubMed and EMBASE medical databases (1969 to week 21 of 2007) was performed using the key words “mice”, “rat”, “rabbit”, “canine”, and “primate” in combination with “subarachnoid hemorrhage”, “model”, and “vasospasm”. Seven techniques were mainly used to induce experimental subarachnoid hemorrhage in closed and open cranium approaches. Among the great number of experimental SAH methods and associated parameters only a fistful reliable models can be identified and recommended for experimental work in mice, rats, rabbits, dogs and nonhuman primates.

Item Type:

Book Section (Book Chapter)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Neurochirurgie

UniBE Contributor:

Marbacher, Serge and Fandino, Javier

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0065-1419

ISBN:

978-3-7091-0352-4

Series:

Acta Neurochirurgica Supplement

Publisher:

Springer

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

16 Sep 2022 11:27

Last Modified:

05 Dec 2022 16:24

Publisher DOI:

10.1007/978-3-7091-0353-1_30

BORIS DOI:

10.48350/172995

URI:

https://boris.unibe.ch/id/eprint/172995

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