Li, Xiao-Yan; Bao, Yu-Feng; Xie, Juan-Juan; Qian, Shu-Xia; Gao, Bin; Xu, Miao; Dong, Yi; Burgunder, Jean-Marc; Wu, Zhi-Ying (2022). The Chinese Version of UHDRS in Huntington's Disease: Reliability and Validity Assessment. Journal of Huntington's disease, 11(4), pp. 407-413. IOS Press 10.3233/JHD-220542
Full text not available from this repository.BACKGROUND
The Unified Huntington's Disease Rating Scale (UHDRS) is a universal scale assessing disease severity of Huntington's disease (HD). However, the English version cannot be widely used in China, and the reliability and validity of the Chinese UHDRS have not yet been confirmed.
OBJECTIVE
To test the reliability and validity of Chinse UHDRS in patients with HD.
METHODS
Between August 2013 and August 2021, 159 HD patients, 40 premanifest HD, and 64 healthy controls were consecutively recruited from two medical centers in China and assessed by Chinese UHDRS. Internal consistency and interrater reliability of the scale were examined. Intercorrelation was performed to analyze the convergent and divergent validity of the scale. A receiver operating characteristic analysis was conducted to explore the optimal cutoff point of each cognitive test.
RESULTS
High internal consistency was found in Chinese UHDRS, and its Cronbach's alpha values of the motor, cognitive, behavioral and functional subscales were 0.954, 0.826, 0.804, and 0.954, respectively. The interrater reliability of the total motor score was 0.960. The convergent and divergent validity revealed that motor, cognitive and functional subscales strongly related to each other except for Problem Behavior Assessment. Furthermore, we not only provided the normal level of each cognitive test in controls, but also gave the optimal cutoff points of cognitive tests between controls and HD patients.
CONCLUSION
We demonstrate for the first time that the translated version of UHDRS is reliable for assessing HD patients in China. This can promote the universal use of UHDRS in clinical practice.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Burgunder, Jean-Marc |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1879-6400 |
Publisher: |
IOS Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
21 Sep 2022 10:30 |
Last Modified: |
20 Dec 2022 00:13 |
Publisher DOI: |
10.3233/JHD-220542 |
PubMed ID: |
36120787 |
Uncontrolled Keywords: |
Chinese Huntington’s disease UHDRS reliability assessment |
URI: |
https://boris.unibe.ch/id/eprint/173087 |
Actions (login required)
 |
Edit item |