A microsurgical bifurcation rabbit model to investigate the effect of high-intensity focused ultrasound on aneurysms: a technical note.

Coluccia, Daniel; Fandino, Javier; Marbacher, Serge; Erhardt, Salome; Kienzler, Jenny; Martin, Ernst; Werner, Beat (2014). A microsurgical bifurcation rabbit model to investigate the effect of high-intensity focused ultrasound on aneurysms: a technical note. Journal of therapeutic ultrasound, 2, p. 21. Biomed Central 10.1186/2050-5736-2-21

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BACKGROUND

Recent clinical studies confirmed the high potential of MR-guided focused ultrasound (MRgFUS) in the field of functional neurosurgery. While its ability for precise thermo-ablation within soft tissue is widely recognized, the impact of high-intensity focused ultrasound (HIFU) on larger vessels is less explored. We used a bifurcation aneurysm model in rabbits to investigate the possible effects on the walls of vascular aneurysms and to assess the risk and prospect of this procedure for managing neurovascular disorders.

METHODS

Experimental bifurcation aneurysms were microsurgically created in New Zealand white rabbits and sonicated using MRgFUS.

RESULTS

A temperature of max. 54°C could be achieved close to the aneurysm, and the shape and size of the aneurysm were noticeably changed, as shown by MR angiography.

CONCLUSIONS

The presented rabbit model proved suitable and capable of being extended to acquire data on the effect of HIFU on aneurysms and larger vessels. The fact that HIFU led to an alteration of the aneurysm without inducing rupture encourages further investigations.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Intensivmedizin
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Neurochirurgie

UniBE Contributor:

Coluccia, Daniel and Erhardt, Salome Aglaia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2050-5736

Publisher:

Biomed Central

Language:

English

Submitter:

Marceline Brodmann

Date Deposited:

21 Sep 2022 10:10

Last Modified:

05 Dec 2022 16:25

Publisher DOI:

10.1186/2050-5736-2-21

PubMed ID:

25512871

Uncontrolled Keywords:

Aneurysm Focused ultrasound Rabbit model Sonication

BORIS DOI:

10.48350/173108

URI:

https://boris.unibe.ch/id/eprint/173108

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