Apoptosis in disease: about shortage and excess.

Brunner, Thomas; Mueller, Christoph (2003). Apoptosis in disease: about shortage and excess. Essays in biochemistry, 39, pp. 119-130. Portland Press 10.1042/bse0390119

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The death of cells by apoptosis is a fundamental event in development and the maintenance of cell homoeostasis. The other side of the coin, however, is that excessive cell death by apoptosis or the lack of apoptosis is often the driving force of many diseases. Whereas reduced apoptosis sensitivity is a basic characteristic of many tumour cells, accelerated tissue cell death and loss of tissue functions is the underlying cause of many auto-immune and inflammatory diseases.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Brunner, Thomas (A), Müller, Christoph (C)

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1744-1358

Publisher:

Portland Press

Language:

English

Submitter:

Christoph Müller

Date Deposited:

23 Sep 2022 10:47

Last Modified:

29 Mar 2023 23:38

Publisher DOI:

10.1042/bse0390119

PubMed ID:

14585078

URI:

https://boris.unibe.ch/id/eprint/173170

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