Mouse Model of Reversible Intestinal Inflammation.

Kwong Chung, Cheong Kc; Brasseit, Jennifer; Althaus-Steiner, Esther; Rihs, Silvia; Mueller, Christoph (2017). Mouse Model of Reversible Intestinal Inflammation. Bio-protocol, 7(6), e2173. 10.21769/BioProtoc.2173

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Current therapies to treat inflammatory bowel disease by dampening excessive inflammatory immune responses have had limited success ( Reinisch et al., 2011 ; Rutgeerts et al., 2005 ; Sandborn et al., 2012 ). To develop new therapeutic interventions, there is a need for better understanding of the mechanisms that are operative during mucosal healing (Pineton de Chambrun et al., 2010 ). To this end, a reversible model of colitis was developed in which colitis induced by adoptive transfer of naïve CD4+ CD45RBhi T cells in lymphopenic mice can be reversed through depletion of colitogenic CD4+ T cells ( Brasseit et al., 2016 ).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Müller, Christoph

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2331-8325

Language:

English

Submitter:

Christoph Müller

Date Deposited:

23 Sep 2022 10:08

Last Modified:

23 Sep 2022 10:08

Publisher DOI:

10.21769/BioProtoc.2173

PubMed ID:

34458484

Uncontrolled Keywords:

Colitis Mucosal healing Relapsing disease Remission

URI:

https://boris.unibe.ch/id/eprint/173183

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