Koster, Kira-Lee; Appenzeller, Christina; Lauber, Arno; Früh, Martin; Schmid, Sabine (2022). Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases. Case reports in oncology, 15(2), pp. 720-725. Karger 10.1159/000525341
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Treatment with sotorasib has shown intracranial complete responses and continued intracranial stabilization in KRAS G12C-mutated non-small-cell lung carcinoma (NSCLC) patients with previously treated, stable brain metastases in a post hoc analysis of the ongoing CodeBreaK 100 trial. We present the case of a patient with KRAS G12C-mutant adenocarcinoma of the lung with active untreated brain metastases with a nearly complete intracranial response only 6 weeks after start of sotorasib illustrating the benefit of sotorasib in patients with active, previously untreated brain metastases in KRAS G12C-mutated NSCLC.
Item Type: |
Journal Article (Further Contribution) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Früh, Martin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1662-6575 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
29 Sep 2022 07:55 |
Last Modified: |
05 Dec 2022 16:25 |
Publisher DOI: |
10.1159/000525341 |
PubMed ID: |
36157699 |
Uncontrolled Keywords: |
KRAS inhibition KRAS-mutated NSCLC NSCLC with active brain metastases |
BORIS DOI: |
10.48350/173365 |
URI: |
https://boris.unibe.ch/id/eprint/173365 |
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