Simon-Martinez, Cristina; Decraene, Lisa; Zielinski, Ingar; Hoare, Brian; Williams, Jacqueline; Mailleux, Lisa; Steenbergen, Bert; Ortibus, Els; Feys, Hilde; Klingels, Katrijn (2022). The impact of brain lesion characteristics and the corticospinal tract wiring on mirror movements in unilateral cerebral palsy. Scientific reports, 12(1), p. 16301. Springer Nature 10.1038/s41598-022-19920-z
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Mirror movements (MM) influence bimanual performance in children with unilateral cerebral palsy (uCP). Whilst MM are related to brain lesion characteristics and the corticospinal tract (CST) wiring pattern, the combined impact of these neurological factors remains unknown. Forty-nine children with uCP (mean age 10y6mo) performed a repetitive squeezing task to quantify similarity (MM-similarity) and strength (MM-intensity) of the MM activity. We used MRI data to evaluate lesion type (periventricular white matter, N = 30; cortico-subcortical, N = 19), extent of ipsilesional damage, presence of bilateral lesions, and damage to basal ganglia, thalamus and corpus callosum. The CST wiring was assessed with Transcranial Magnetic Stimulation (17 CSTcontralateral, 16 CSTipsilateral, 16 CSTbilateral). Data was analyzed with regression analyses. In the more-affected hand, MM-similarity and intensity were higher with CSTbilateral/ipsilateral. In the less-affected hand, MM-similarity was higher in children with (1) CSTcontra with CSC lesions, (2) CSTbilat/ipsi with PVL lesions and (3) CSTbilat/ipsi with unilateralized lesions. MM-intensity was higher with larger damage to the corpus callosum and unilateral lesions. A complex combination of neurological factors influences MM characteristics, and the mechanisms differ between hands.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics |
UniBE Contributor: |
Simon-Martinez, Cristina |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Anette van Dorland |
Date Deposited: |
03 Oct 2022 10:25 |
Last Modified: |
06 Jan 2023 09:11 |
Publisher DOI: |
10.1038/s41598-022-19920-z |
PubMed ID: |
36175439 |
BORIS DOI: |
10.48350/173424 |
URI: |
https://boris.unibe.ch/id/eprint/173424 |
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