Giraudier, Manon; Ventura-Bort, Carlos; Burger, Andreas M; Claes, Nathalie; D'Agostini, Martina; Fischer, Rico; Franssen, Mathijs; Kaess, Michael; Koenig, Julian; Liepelt, Roman; Nieuwenhuis, Sander; Sommer, Aldo; Usichenko, Taras; Van Diest, Ilse; von Leupoldt, Andreas; Warren, Christopher M; Weymar, Mathias (2022). Evidence for a modulating effect of transcutaneous auricular vagus nerve stimulation (taVNS) on salivary alpha-amylase as indirect noradrenergic marker: A pooled mega-analysis. Brain stimulation, 15(6), pp. 1378-1388. Elsevier 10.1016/j.brs.2022.09.009
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BACKGROUND
Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has received tremendous attention as a potential neuromodulator of cognitive and affective functions, which likely exerts its effects via activation of the locus coeruleus-noradrenaline (LC-NA) system. Reliable effects of taVNS on markers of LC-NA system activity, however, have not been demonstrated yet.
METHODS
The aim of the present study was to overcome previous limitations by pooling raw data from a large sample of ten taVNS studies (371 healthy participants) that collected salivary alpha-amylase (sAA) as a potential marker of central NA release.
RESULTS
While a meta-analytic approach using summary statistics did not yield any significant effects, linear mixed model analyses showed that afferent stimulation of the vagus nerve via taVNS increased sAA levels compared to sham stimulation (b = 0.16, SE = 0.05, p = 0.001). When considering potential confounders of sAA, we further replicated previous findings on the diurnal trajectory of sAA activity.
CONCLUSION(S)
Vagal activation via taVNS increases sAA release compared to sham stimulation, which likely substantiates the assumption that taVNS triggers NA release. Moreover, our results highlight the benefits of data pooling and data sharing in order to allow stronger conclusions in research.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy |
UniBE Contributor: |
Kaess, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1935-861X |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
04 Oct 2022 14:12 |
Last Modified: |
24 Apr 2023 14:50 |
Publisher DOI: |
10.1016/j.brs.2022.09.009 |
PubMed ID: |
36183953 |
Uncontrolled Keywords: |
Biomarker Data pooling Non-invasive vagus nerve stimulation Noradrenaline sAA tVNS |
BORIS DOI: |
10.48350/173481 |
URI: |
https://boris.unibe.ch/id/eprint/173481 |
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