Anderson, Collene E; Birkhäuser, Veronika; Liechti, Martina D; Jordan, Xavier; Luca, Eugenia; Möhr, Sandra; Pannek, Jürgen; Kessler, Thomas M; Brinkhof, Martin W G (2023). Sex differences in urological management during spinal cord injury rehabilitation: results from a prospective multicenter longitudinal cohort study. Spinal cord, 61(1), pp. 43-50. Springer Nature 10.1038/s41393-022-00860-4
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STUDY DESIGN
Prospective, multicenter, longitudinal cohort study.
OBJECTIVES
To describe female-male differences in first-line urological management during spinal cord injury (SCI) rehabilitation.
SETTING
Inpatient specialized post-acute SCI rehabilitation in Switzerland.
METHODS
Data on bladder storage medication (antimuscarinic and beta-3 agonist) use, suprapubic catheter placement, demographic and SCI characteristics was collected within 40 days of SCI and at rehabilitation discharge from May 2013-September 2021. Prevalence and indicators of bladder storage medication and suprapubic catheter use at discharge were investigated with sex-stratified descriptive and logistic regression analyses.
RESULTS
In 748 patients (219 females, 29%), bladder storage medication use at discharge had a prevalence of 24% (95% CI: 18-29%) for females and 30% (95% CI: 26-34%) for males and was indicated by cervical AIS grade A, B, C and traumatic SCI in both sexes. Thoracic AIS grade A, B, C SCI (males), and lumbar/sacral AIS grade A, B, C SCI (females) predicted higher odds of bladder storage medication use (SCI characteristic*sex interaction, p < 0.01). Prevalence of suprapubic catheter use at discharge was 22% (95% CI: 17-28%) for females and 17% (95% CI: 14-20%) for males. Suprapubic catheter use was indicated by cervical AIS grade A, B, C SCI, and age >60 in both sexes. Females with thoracic grade A, B, C SCI tended to have higher odds of suprapubic catheter use (SCI characteristic*sex interaction, p = 0.013).
CONCLUSIONS
We identified sex differences in urological management especially in persons with AIS grade C or higher sub-cervical SCI. There is scope for well-powered, female-specific research in SCI in order to understand the underlying mechanisms and support patient-tailored management.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology |
UniBE Contributor: |
Pannek, Jürgen |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1476-5624 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
14 Oct 2022 12:43 |
Last Modified: |
14 Jan 2023 00:14 |
Publisher DOI: |
10.1038/s41393-022-00860-4 |
PubMed ID: |
36224336 |
BORIS DOI: |
10.48350/173746 |
URI: |
https://boris.unibe.ch/id/eprint/173746 |
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