Sex differences in urological management during spinal cord injury rehabilitation: results from a prospective multicenter longitudinal cohort study.

Anderson, Collene E; Birkhäuser, Veronika; Liechti, Martina D; Jordan, Xavier; Luca, Eugenia; Möhr, Sandra; Pannek, Jürgen; Kessler, Thomas M; Brinkhof, Martin W G (2023). Sex differences in urological management during spinal cord injury rehabilitation: results from a prospective multicenter longitudinal cohort study. Spinal cord, 61(1), pp. 43-50. Springer Nature 10.1038/s41393-022-00860-4

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STUDY DESIGN

Prospective, multicenter, longitudinal cohort study.

OBJECTIVES

To describe female-male differences in first-line urological management during spinal cord injury (SCI) rehabilitation.

SETTING

Inpatient specialized post-acute SCI rehabilitation in Switzerland.

METHODS

Data on bladder storage medication (antimuscarinic and beta-3 agonist) use, suprapubic catheter placement, demographic and SCI characteristics was collected within 40 days of SCI and at rehabilitation discharge from May 2013-September 2021. Prevalence and indicators of bladder storage medication and suprapubic catheter use at discharge were investigated with sex-stratified descriptive and logistic regression analyses.

RESULTS

In 748 patients (219 females, 29%), bladder storage medication use at discharge had a prevalence of 24% (95% CI: 18-29%) for females and 30% (95% CI: 26-34%) for males and was indicated by cervical AIS grade A, B, C and traumatic SCI in both sexes. Thoracic AIS grade A, B, C SCI (males), and lumbar/sacral AIS grade A, B, C SCI (females) predicted higher odds of bladder storage medication use (SCI characteristic*sex interaction, p < 0.01). Prevalence of suprapubic catheter use at discharge was 22% (95% CI: 17-28%) for females and 17% (95% CI: 14-20%) for males. Suprapubic catheter use was indicated by cervical AIS grade A, B, C SCI, and age >60 in both sexes. Females with thoracic grade A, B, C SCI tended to have higher odds of suprapubic catheter use (SCI characteristic*sex interaction, p = 0.013).

CONCLUSIONS

We identified sex differences in urological management especially in persons with AIS grade C or higher sub-cervical SCI. There is scope for well-powered, female-specific research in SCI in order to understand the underlying mechanisms and support patient-tailored management.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Pannek, Jürgen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1476-5624

Publisher:

Springer Nature

Language:

English

Submitter:

Pubmed Import

Date Deposited:

14 Oct 2022 12:43

Last Modified:

14 Jan 2023 00:14

Publisher DOI:

10.1038/s41393-022-00860-4

PubMed ID:

36224336

BORIS DOI:

10.48350/173746

URI:

https://boris.unibe.ch/id/eprint/173746

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