Huang, Yan; Zhang, Han; Fan, Xin; Wang, Junpeng; Yin, Yuzhen; Zhang, Yu; Shi, Kuangyu; Yu, Fei (2023). The Role of Gut Microbiota and Trimethylamine N-oxide in Cardiovascular Diseases. Journal of cardiovascular translational research JCTR, 16(3), pp. 581-589. Springer 10.1007/s12265-022-10330-0
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Changes in the intestinal flora and its metabolites have been associated with cardiovascular disease (CVD). Short-chain fatty acids, bile acids, and especially trimethylamine N-oxide (TMAO), an endothelial toxic factor produced by gut microbiota from phosphatidylcholine in meat, have been identified to be closely related to endothelial cell dysfunction as well as tightly affiliated with CVD, the two main types being coronary artery disease (CAD) and coronary microvascular disease (CMVD). We discuss how changes in the gut flora and the metabolite TMAO contribute to the development of CAD and CMVD. The above insight might serve as a stepping stone for novel CAD and CMVD diagnostics and therapies centered on microbiota.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Shi, Kuangyu |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1937-5387 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
18 Oct 2022 10:19 |
Last Modified: |
28 Jun 2023 00:11 |
Publisher DOI: |
10.1007/s12265-022-10330-0 |
PubMed ID: |
36251229 |
Uncontrolled Keywords: |
Coronary artery disease Coronary microvascular diseases Gut microbiota Trimethylamine N-oxide |
BORIS DOI: |
10.48350/173839 |
URI: |
https://boris.unibe.ch/id/eprint/173839 |
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