Evaluation of peripheral nerve regeneration in Murphy Roths Large mouse strain following transection injury.

Milek, David; Echternacht, Scott R; LaGuardia, Jonnby; LaBarge, Dalton; Turpin, Loel; Grobbelaar, Adriaan; Leckenby, Jonathan I (2023). Evaluation of peripheral nerve regeneration in Murphy Roths Large mouse strain following transection injury. Regenerative medicine, 18(1), pp. 37-53. Future Medicine 10.2217/rme-2022-0098

Full text not available from this repository.

Aim: Murphy Roths Large (MRL/MpJ) mice have demonstrated the ability to heal with minimal or no scar formation in several tissue types. In order to identify a novel animal model, this study sought to evaluate whether this attribute applies to peripheral nerve regeneration. Materials & methods: This was a two-phase study. 6-week-old male mice were divided into two interventional groups: nerve repair and nerve graft. The MRL/MpJ was compared with the C57BL/6J strain for evaluation of both functional and histological outcomes. Results: MRL/MpJ strain demonstrated superior axon myelination and less scar formation, however functional outcomes did not show significant difference between strains. Conclusion: Superior histological outcomes did not translate into superior peripheral nerve regeneration in MRL/MpJ strain.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery
UniBE Contributor:	Grobbelaar, Adriaan Ockert
Subjects:	600 Technology > 610 Medicine & health
ISSN:	1746-0751
Publisher:	Future Medicine
Language:	English
Submitter:	Pubmed Import
Date Deposited:	19 Oct 2022 12:41
Last Modified:	09 Dec 2022 00:14
Publisher DOI:	10.2217/rme-2022-0098
PubMed ID:	36255077
Uncontrolled Keywords:	MRL/MpJ mice strain animal model axon regeneration nerve injury nerve regeneration nerve regeneration outcomes nerve scar peripheral nerve sciatic function index sciatic nerve
URI:	https://boris.unibe.ch/id/eprint/173895