Milek, David; Echternacht, Scott R; LaGuardia, Jonnby; LaBarge, Dalton; Turpin, Loel; Grobbelaar, Adriaan; Leckenby, Jonathan I (2023). Evaluation of peripheral nerve regeneration in Murphy Roths Large mouse strain following transection injury. Regenerative medicine, 18(1), pp. 37-53. Future Medicine 10.2217/rme-2022-0098
Full text not available from this repository. (Request a copy)Aim: Murphy Roths Large (MRL/MpJ) mice have demonstrated the ability to heal with minimal or no scar formation in several tissue types. In order to identify a novel animal model, this study sought to evaluate whether this attribute applies to peripheral nerve regeneration. Materials & methods: This was a two-phase study. 6-week-old male mice were divided into two interventional groups: nerve repair and nerve graft. The MRL/MpJ was compared with the C57BL/6J strain for evaluation of both functional and histological outcomes. Results: MRL/MpJ strain demonstrated superior axon myelination and less scar formation, however functional outcomes did not show significant difference between strains. Conclusion: Superior histological outcomes did not translate into superior peripheral nerve regeneration in MRL/MpJ strain.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery |
UniBE Contributor: |
Grobbelaar, Adriaan Ockert |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1746-0751 |
Publisher: |
Future Medicine |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
19 Oct 2022 12:41 |
Last Modified: |
09 Dec 2022 00:14 |
Publisher DOI: |
10.2217/rme-2022-0098 |
PubMed ID: |
36255077 |
Uncontrolled Keywords: |
MRL/MpJ mice strain animal model axon regeneration nerve injury nerve regeneration nerve regeneration outcomes nerve scar peripheral nerve sciatic function index sciatic nerve |
URI: |
https://boris.unibe.ch/id/eprint/173895 |
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