Structural alterations of the motor cortex and higher order cortical areas suggest early neurodevelopmental origin of catatonia in schizophrenia.

Walther, Sebastian; Nadesalingam, Niluja; Nuoffer, Melanie; Kyrou, Alexandra; Wüthrich, Florian; Lefebvre, Stephanie (2024). Structural alterations of the motor cortex and higher order cortical areas suggest early neurodevelopmental origin of catatonia in schizophrenia. Schizophrenia Research, 263, pp. 131-138. Elsevier 10.1016/j.schres.2022.10.004

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The neurobiology of catatonia is still poorly understood. Particularly structural MRI studies yielded conflicting results. Heterogeneity of findings was suggested to stem from specifics of different rating scales. This study sought to test grey matter differences between patients with catatonia, patients without catatonia, and healthy controls using the two main instruments of catatonia rating. We included 98 patients with schizophrenia spectrum disorders and 42 healthy controls. Catatonia was measured using the Bush Francis Catatonia Rating Scale and the Northoff Catatonia Rating Scale. According to these scales, patients were classified into those with and those without catatonia. We tested whole brain grey matter volume, cortical thickness, and local gyrification across groups. Both catatonia rating scales correlated at tau = 0.65 but failed to classify identical subjects as catatonia patients. However, group differences in grey matter parameters were broadly similar with either rating scale to identify catatonia cases. Catatonia patients had reduced grey matter volume compared to controls in a large network including orbitofrontal cortex, cingulate, thalamus, and amygdala. While there was no group difference in cortical thickness, catatonia patients had increased local gyrification in premotor, motor, and parietal cortices compared to controls. Hypergyrification of the motor cortex and higher order cortical areas was found in catatonia patients compared to patients without catatonia. Both catatonia rating scales find similar symptom severity and group differences in grey matter indices. Catatonia is linked to reduced grey matter volume and increased local gyrification, suggesting some impact of early neurodevelopmental insults.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Walther, Sebastian, Nadesalingam, Niluja, Nuoffer, Melanie Gabriela, Kyrou, Alexandra, Wüthrich, Florian, Lefebvre, Stéphanie

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0920-9964

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

24 Oct 2022 14:13

Last Modified:

22 Dec 2023 00:11

Publisher DOI:

10.1016/j.schres.2022.10.004

PubMed ID:

36272843

Uncontrolled Keywords:

Catatonia Cortical gyrification Cortical thickness Grey matter volume MRI Schizophrenia Voxel-based morphometry

BORIS DOI:

10.48350/174024

URI:

https://boris.unibe.ch/id/eprint/174024

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