Allio, Ileana Rosely; Caobelli, Federico; Popescu, Cristina Elena; Haaf, Philip; Alberts, Ian; Frey, Simon M; Zellweger, Michael J (2023). Low-dose coronary artery calcium scoring compared to the standard protocol. Journal of nuclear cardiology, 30(3), pp. 1191-1198. Springer 10.1007/s12350-022-03120-3
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BACKGROUND
We aimed to compare coronary artery calcium scoring (CACS) with computed tomography (CT) with 80 and 120 kVp in a large patient population and to establish whether there is a difference in risk classification between the two scores.
METHODS
Patients with suspected CAD undergoing MPS were included. All underwent standard CACS assessment with 120-kVp tube voltage and with 80 kVp. Two datasets (low-dose and standard) were generated and compared. Risk classes (0 to 25, 25 to 50, 50 to 75, 75 to 90, and > 90%) were recorded.
RESULTS
1511 patients were included (793 males, age 69 ± 9.1 years). There was a very good correlation between scores calculated with 120 and 80 kVp (R = 0.94, R2 = 0.88, P < .001), with Bland-Altman limits of agreement of - 563.5 to 871.9 and a bias of - 154.2. The proportion of patients assigned to the < 25% percentile class (P = .03) and with CACS = 0 differed between the two protocols (n = 264 vs 437, P < .001).
CONCLUSION
In a large patient population, despite a good correlation between CACS calculated with standard and low-dose CT, there is a systematic underestimation of CACS with the low-dose protocol. This may have an impact especially on the prognostic value of the calcium score, and the established "power of zero" may no longer be warranted if CACS is assessed with low-dose CT.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Caobelli, Federico, Alberts, Ian Leigh |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1071-3581 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
28 Oct 2022 15:23 |
Last Modified: |
13 Jun 2023 00:12 |
Publisher DOI: |
10.1007/s12350-022-03120-3 |
PubMed ID: |
36289163 |
Uncontrolled Keywords: |
Coronary calcium score attenuation correction coronary CT low-dose CT myocardial perfusion imaging |
BORIS DOI: |
10.48350/174225 |
URI: |
https://boris.unibe.ch/id/eprint/174225 |
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