Raptis, Catherine E; Berger, Christoph T; Ciurea, Adrian; Andrey, Diego O; Polysopoulos, Christos; Lescuyer, Pierre; Maletic, Tanja; Riek, Myriam; Scherer, Almut; von Loga, Isabell; Safford, Judith; Lauper, Kim; Möller, Burkhard; Vuilleumier, Nicolas; Finckh, Axel; Rubbert-Roth, Andrea (2022). Type of mRNA COVID-19 vaccine and immunomodulatory treatment influence humoral immunogenicity in patients with inflammatory rheumatic diseases. Frontiers in immunology, 13(1016927), p. 1016927. Frontiers Research Foundation 10.3389/fimmu.2022.1016927
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Patients with inflammatory rheumatic diseases (IRD) are at increased risk for worse COVID-19 outcomes. Identifying whether mRNA vaccines differ in immunogenicity and examining the effects of immunomodulatory treatments may support COVID-19 vaccination strategies. We aimed to conduct a long-term, model-based comparison of the humoral immunogenicity following BNT162b2 and mRNA-1273 vaccination in a cohort of IRD patients. Patients from the Swiss IRD cohort (SCQM), who assented to mRNA COVID-19 vaccination were recruited between 3/2021-9/2021. Blood samples at baseline, 4, 12, and 24 weeks post second vaccine dose were tested for anti-SARS-CoV-2 spike IgG (anti-S1). We examined differences in antibody levels depending on the vaccine and treatment at baseline while adjusting for age, disease, and past SARS-CoV-2 infection. 565 IRD patients provided eligible samples. Among monotherapies, rituximab, abatacept, JAKi, and TNFi had the highest odds of reduced anti-S1 responses compared to no medication. Patients on specific combination therapies showed significantly lower antibody responses than those on monotherapy. Irrespective of the disease, treatment, and past SARS-CoV-2 infection, the odds of higher antibody levels at 4, 12, and 24 weeks post second vaccine dose were, respectively, 3.4, 3.8, and 3.8 times higher with mRNA-1273 versus BNT162b2 (p < 0.0001). With every year of age, the odds ratio of higher peak humoral immunogenicity following mRNA-1273 versus BNT162b2 increased by 5% (p < 0.001), indicating a particular benefit for elderly patients. Our results suggest that in IRD patients, two-dose vaccination with mRNA-1273 versus BNT162b2 results in higher anti-S1 levels, even more so in elderly patients.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology |
UniBE Contributor: |
Möller, Burkhard |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1664-3224 |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
01 Nov 2022 14:20 |
Last Modified: |
05 Dec 2022 16:27 |
Publisher DOI: |
10.3389/fimmu.2022.1016927 |
PubMed ID: |
36311791 |
Uncontrolled Keywords: |
BNT162b2 SARS-CoV-2 anti-spike-IgG immunosuppression mRNA-1273 rheumatic disease vaccination waning immunity |
BORIS DOI: |
10.48350/174375 |
URI: |
https://boris.unibe.ch/id/eprint/174375 |
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