Coupling between the prelimbic cortex, nucleus reuniens, and hippocampus during NREM sleep remains stable under cognitive and homeostatic demands.

Bozic, Ivan; Rusterholz, Thomas; Mikutta, Christian; Del Rio Bermudez, Carlos; Nissen, Christoph; Adamantidis, Antoine (2023). Coupling between the prelimbic cortex, nucleus reuniens, and hippocampus during NREM sleep remains stable under cognitive and homeostatic demands. European journal of neuroscience, 57(1), pp. 106-128. Wiley 10.1111/ejn.15853

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The interplay between the medial prefrontal cortex and hippocampus during non-REM (NREM) sleep contributes to the consolidation of contextual memories. To assess the role of the thalamic nucleus reuniens (Nre) in this interaction, we investigated the coupling of neuro-oscillatory activities between prelimbic cortex, Nre, and hippocampus across sleep states and their role in the consolidation of contextual memories using multi-site electrophysiological recordings and optogenetic manipulations. We showed that ripples are time-locked to the Up state of cortical slow waves, the transition from Up to Down state in thalamic slow waves, the troughs of cortical spindles, and the peaks of thalamic spindles during spontaneous sleep, rebound sleep, and sleep following a fear conditioning task. In addition, spiking activity in Nre increased before hippocampal ripples and the phase-locking of hippocampal ripples and thalamic spindles during NREM sleep was stronger after acquisition of a fear memory. We showed that optogenetic inhibition of Nre neurons reduced phase-locking of ripples to cortical slow waves in the ventral hippocampus while their activation altered the preferred phase of ripples to slow waves in ventral and dorsal hippocampi. However, none of these optogenetic manipulations of Nre during sleep after acquisition of fear conditioning did alter sleep-dependent memory consolidation. Collectively, these results showed that Nre is central in modulating hippocampus and cortical rhythms during NREM sleep.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie

UniBE Contributor:

Bozic, Ivan, Rusterholz, Thomas, Mikutta, Christian, Del Rio Bermudez, Carlos, Nissen, Christoph, Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1460-9568

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

01 Nov 2022 12:58

Last Modified:

05 Jan 2023 00:14

Publisher DOI:

10.1111/ejn.15853

PubMed ID:

36310348

Uncontrolled Keywords:

Nucleus reuniens thalami cortico-hippocampal communication memory consolidation oscillations sleep

BORIS DOI:

10.48350/174380

URI:

https://boris.unibe.ch/id/eprint/174380

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