Linnik, Janina; Syedbasha, Mohammedyaseen; Kaltenbach, Hans-Michael; Vogt, Dominik; Hollenstein, Yvonne; Kaufmann, Lukas; Cantoni, Nathan; Ruosch-Girsberger, Sabine; Müller, Antonia M S; Schanz, Urs; Pabst, Thomas; Stüssi, Georg; Weisser, Maja; Halter, Jörg; Stelling, Jörg; Egli, Adrian (2022). Association of Host Factors With Antibody Response to Seasonal Influenza Vaccination in Allogeneic Hematopoietic Stem Cell Transplant Patients. The journal of infectious diseases, 225(8), pp. 1482-1493. Oxford University Press 10.1093/infdis/jiab391
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BACKGROUND
Influenza vaccination efficacy is reduced after hematopoietic stem cell transplantation (HSCT) and patient factors determining vaccination outcomes are still poorly understood.
METHODS
We investigated the antibody response to seasonal influenza vaccination in 135 HSCT patients and 69 healthy volunteers (HVs) in a prospective observational multicenter cohort study. We identified patient factors associated with hemagglutination inhibition titers against A/California/2009/H1N1, A/Texas/2012/H3N2, and B/Massachusetts/2012 by multivariable regression on the observed titer levels and on seroconversion/seroprotection categories for comparison.
RESULTS
Both regression approaches yielded consistent results but regression on titers estimated associations with higher precision. HSCT patients required 2 vaccine doses to achieve average responses comparable to a single dose in HVs. Prevaccination titers were positively associated with time after transplantation, confirming that HSCT patients can elicit potent antibody responses. However, an unrelated donor, absolute lymphocyte counts below the normal range, and treatment with calcineurin inhibitors lowered the odds of responding.
CONCLUSIONS
HSCT patients show a highly heterogeneous vaccine response but, overall, patients benefited from the booster shot and can acquire seroprotective antibodies over the years after transplantation. Several common patient factors lower the odds of responding, urging identification of additional preventive strategies in the poorly responding groups.
CLINICAL TRIALS REGISTRATION
NCT03467074.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Pabst, Thomas Niklaus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1537-6613 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Rebeka Gerber |
Date Deposited: |
03 Nov 2022 07:05 |
Last Modified: |
05 Dec 2022 16:27 |
Publisher DOI: |
10.1093/infdis/jiab391 |
PubMed ID: |
34415049 |
Uncontrolled Keywords: |
categorical regression graft-versus-host disease hemagglutination inhibition titer hematopoietic stem cell transplantation immunosuppression influenza sequential model seroconversion vaccination |
BORIS DOI: |
10.48350/174435 |
URI: |
https://boris.unibe.ch/id/eprint/174435 |
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