Béreau, Matthieu; Castrioto, Anna; Lhommée, Eugénie; Maillet, Audrey; Gérazime, Aurélie; Bichon, Amélie; Pélissier, Pierre; Schmitt, Emmanuelle; Klinger, Hélène; Longato, Nadine; Fraix, Valérie; Benatru, Isabelle; Durif, Franck; Azulay, Jean-Philippe; Moro, Elena; Broussolle, Emmanuel; Tranchant, Christine; Anheim, Mathieu; Thobois, Stéphane and Krack, Paul (2022). Fatigue in de novo Parkinson's Disease: Expanding the Neuropsychiatric Triad? Journal of Parkinson's disease, 12(4), pp. 1329-1337. IOS Press 10.3233/JPD-213116
Full text not available from this repository. (Request a copy)BACKGROUND
Fatigue is a frequent and troublesome symptom present from the early stages of Parkinson's disease (PD).
OBJECTIVE
To examine the relationship between fatigue and the neuropsychiatric triad, which includes apathy, depression, and anxiety, in de novo PD.
METHODS
We performed a cross-sectional study including 197 patients with de novo PD and assessed fatigue using the Parkinson's Disease Fatigue Scale (PDFS-16). We evaluated motor status using the Unified Parkinson's Disease Rating Scale (UPDRS) part III score and evaluated neuropsychiatric status using the Ardouin Scale of Behavior in Parkinson's Disease (ASBPD). We carried out univariate and multivariate analyses to model association between motor signs, non-motor signs, and fatigue risk.
RESULTS
Frequency of fatigue (28.9%) was of the same order of magnitude as that of apathy. PD patients with fatigue reported a lower quality of life than patients without fatigue (p < 0.0001). The ASBPD showed that patients with fatigue had higher scores for depressed mood (p < 0.0001), anxiety (p < 0.0001), and apathy (p < 0.0001). In the univariate analysis, fatigue score was positively correlated with apathy, depression, anxiety, and the neuropsychiatric triad as a whole, and to a lesser extent with female sex, hyperemotivity, and the UPDRS part III score. In the multivariate analysis, after adjusting for sex and motor status, the fatigue score remained significantly correlated with apathy (OR = 11.17 [4.33-28.78], p < 0.0001) and depression (OR = 4.28 [1.39-13.12], p = 0.01), but not with anxiety (OR = 0.94 [0.34-2.58], p = 0.9).
CONCLUSION
We propose that the neuropsychiatric triad could be expanded to include fatigue.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Krack, Paul |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1877-718X |
Publisher: |
IOS Press |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
03 Nov 2022 12:00 |
Last Modified: |
05 Dec 2022 16:27 |
Publisher DOI: |
10.3233/JPD-213116 |
PubMed ID: |
35253781 |
Uncontrolled Keywords: |
Parkinson’s disease apathy depression fatigue motivation |
URI: |
https://boris.unibe.ch/id/eprint/174463 |
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