Zhang, Min; Quan, Weiwei; Zhu, Tianqi; Feng, Shuo; Huang, Xinyun; Meng, Hongping; Du, Run; Zhu, Zhengbin; Qu, Xuezheng; Li, Ping; Cui, Yuke; Shi, Kuangyu; Yan, Xiaoxiang; Zhang, Ruiyan; Li, Biao (2023). [68Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling. European journal of nuclear medicine and molecular imaging, 50(3), pp. 839-848. Springer 10.1007/s00259-022-06015-0
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PURPOSE
To assess predictive value of 68Ga-labeled fibroblast activation protein inhibitor-04 ([68Ga]Ga-DOTA-FAPI-04) PET/MR for late left ventricular (LV) remodeling in patients with ST-segment elevated myocardial infarction (STEMI).
METHODS
Twenty-six patients with STEMI were included in the study. [68Ga]Ga-DOTA-FAPI-04 PET/MR was performed at baseline and at average 12 months after STEMI. LV remodeling was defined as >10% increase in LV end-systolic volume (LVESV) from baseline to 12 months.
RESULTS
The LV remodeling group demonstrated higher [68Ga]Ga-DOTA-FAPI-04 uptake volume (UV) at baseline than the non-LV remodeling group (p < 0.001). [68Ga]Ga-DOTA-FAPI-04 UV at baseline was a significant predictor (OR = 1.048, p = 0.011) for LV remodeling at 12 months after STEMI. Compared to clinical information, MR imaging and cardiac function parameters at baseline, [68Ga]Ga-DOTA-FAPI-04 UV demonstrated better predictive ability (AUC = 0.938, p < 0.001) for late LV remodeling, with sensitivity of 100.0% and specificity of 81.3%.
CONCLUSIONS
[68Ga]Ga-DOTA-FAPI-04 PET/MR is an effective tool to non-invasively quantify myocardial fibroblasts activation, and baseline [68Ga]Ga-DOTA-FAPI-04 UV may have potential predictive value for late LV remodeling.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Shi, Kuangyu |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1619-7089 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
04 Nov 2022 12:12 |
Last Modified: |
20 Jan 2023 00:14 |
Publisher DOI: |
10.1007/s00259-022-06015-0 |
PubMed ID: |
36326870 |
Uncontrolled Keywords: |
Acute myocardial infarction Fibroblast activation protein inhibitor Left ventricular remodeling Myocardial fibrosis PET/MR |
BORIS DOI: |
10.48350/174487 |
URI: |
https://boris.unibe.ch/id/eprint/174487 |
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