Immunoreactive trypsinogen in healthy newborns and infants with cystic fibrosis.

Fingerhut, Ralph; Rueegg, Corina Silvia; Imahorn, Orell; Pedersen, Eva Sophie Lunde; Kuehni, Claudia Elisabeth; Gallati, Sabina; Regamey, Nicolas; Barben, Jürg (2023). Immunoreactive trypsinogen in healthy newborns and infants with cystic fibrosis. Archives of disease in childhood. Fetal and neonatal edition, 108(2), pp. 176-181. BMJ Publishing Group 10.1136/archdischild-2021-323549

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OBJECTIVE

Newborn screening (NBS) for cystic fibrosis (CF) was introduced in Switzerland in 2011 based on an immunoreactive trypsinogen (IRT)-DNA-IRT protocol. CF diagnosis was confirmed by sweat test and/or genetics but remained inconclusive for some newborns (cystic fibrosis transmembrane conductance regulator related metabolic syndrome (CRMS)/CF screen positive, inconclusive diagnosis (CFSPID)). We aimed to (1) Describe IRT levels in healthy newborns in the first year of life and by gestational age (GA), and (2) Compare IRT at two time points between healthy newborns and newborns with CF and CRMS/CFSPID.

DESIGN

Retrospective study.

SETTING

National NBS database.

PATIENTS

All children with an IRT measurement by heel prick test from 2011 to 2019.

INTERVENTIONS

None.

MAIN OUTCOME MEASURES

IRT values were extracted from the National NBS Laboratory, and clinical characteristics of positively screened children from the CF-NBS database. Second IRT assessment in positively screened children was usually performed after 18-24 days. We calculated internal IRT Z-Scores and multiples of the median to compare our results across different laboratory tools.

RESULTS

Among 815 899 children; 232 were diagnosed with CF, of whom 36 had meconium ileus (MI); 27 had CRMS/CFSPID. Among all samples analysed, mean IRT Z-Scores were higher for newborns with GA <33 weeks and ≥43 weeks (all Z-Scores >0.11) compared with term babies (all Z-Scores ≤0.06). Repeated IRT Z-Scores after a median (IQR) of 19 (17-22) days remained high for infants with CF with or without MI but decreased for infants with CRMS/CFSPID.

CONCLUSIONS

Measurement of a second IRT value can help distinguish between children with CRMS/CFSPID and CF, early in life.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

UniBE Contributor:

Pedersen, Eva Sophie Lunde, Kühni, Claudia, Gallati, Sabina

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1468-2052

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

10 Nov 2022 14:25

Last Modified:

15 Mar 2023 10:57

Publisher DOI:

10.1136/archdischild-2021-323549

PubMed ID:

36351789

Uncontrolled Keywords:

Cystic Fibrosis Neonatology

BORIS DOI:

10.48350/174628

URI:

https://boris.unibe.ch/id/eprint/174628

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