Hemodynamic Modeling of the Intrarenal Circulation

M'rabet Bensalah, Khadija; Uehlinger, Dominik; Kalicki, Robert; Czerwinska, J (2013). Hemodynamic Modeling of the Intrarenal Circulation. Annals of biomedical engineering, 41(12), pp. 2630-2644. Cambridge: Springer 10.1007/s10439-013-0865-8

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Three dimensional, time dependent numerical simulations of healthy and pathological conditions in a model kidney were performed. Blood flow in a kidney is not commonly investigated by computational approach, in contrast for example, to the flow in a heart. The flow in a kidney is characterized by relatively small Reynolds number (100 < Re < 0.01-laminar regime). The presented results give insight into the structure of such flow, which is hard to measure in vivo. The simulations have suggested that venous thrombosis is more likely than arterial thrombosis-higher shear rate observed. The obtained maximum velocity, as a result of the simulations, agrees with the observed in vivo measurements. The time dependent simulations show separation regimes present in the vicinity of the maximum pressure value. The pathological constriction introduced to the arterial geometry leads to the changes in separation structures. The constriction of a single vessel affects flow in the whole kidney. Pathology results in different flow rate values in healthy and affected branches, as well as, different pulsate cycle characteristic for the whole system.

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