Hemodynamic Modeling of the Intrarenal Circulation

M'rabet Bensalah, Khadija; Uehlinger, Dominik; Kalicki, Robert; Czerwinska, J (2013). Hemodynamic Modeling of the Intrarenal Circulation. Annals of biomedical engineering, 41(12), pp. 2630-2644. Cambridge: Springer 10.1007/s10439-013-0865-8

[img] Text
art%3A10.1007%2Fs10439-013-0865-8.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy
[img]
Preview
Text
10439_2013_Article_865.pdf - Other
Available under License Publisher holds Copyright.

Download (1MB) | Preview

Three dimensional, time dependent numerical simulations of healthy and pathological conditions in a model kidney were performed. Blood flow in a kidney is not commonly investigated by computational approach, in contrast for example, to the flow in a heart. The flow in a kidney is characterized by relatively small Reynolds number (100 < Re < 0.01-laminar regime). The presented results give insight into the structure of such flow, which is hard to measure in vivo. The simulations have suggested that venous thrombosis is more likely than arterial thrombosis-higher shear rate observed. The obtained maximum velocity, as a result of the simulations, agrees with the observed in vivo measurements. The time dependent simulations show separation regimes present in the vicinity of the maximum pressure value. The pathological constriction introduced to the arterial geometry leads to the changes in separation structures. The constriction of a single vessel affects flow in the whole kidney. Pathology results in different flow rate values in healthy and affected branches, as well as, different pulsate cycle characteristic for the whole system.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Nephrologie / Hypertonie
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension

UniBE Contributor:

M'rabet Bensalah, Khadija; Uehlinger, Dominik; Kalicki, Robert and Czerwinska, Justyna

Subjects:

600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

0090-6964

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:42

Last Modified:

17 Sep 2019 16:12

Publisher DOI:

10.1007/s10439-013-0865-8

PubMed ID:

23887878

BORIS DOI:

10.7892/boris.17473

URI:

https://boris.unibe.ch/id/eprint/17473 (FactScience: 225253)

Actions (login required)

Edit item Edit item
Provide Feedback