Pape, Janna; Levy, Jérémy; von Wolff, Michael (2023). Hormone replacement cycles are associated with a higher risk of hypertensive disorders: retrospective cohort study in singleton and twin pregnancies. BJOG : an international journal of obstetrics and gynaecology, 130(4), pp. 377-386. Wiley 10.1111/1471-0528.17343
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BJOG_-_2022_-_Pape_-_Hormone_replacement_cycles_are_associated_with_a_higher_risk_of_hypertensive_disorders_retrospective.pdf - Accepted Version Available under License Publisher holds Copyright. Download (427kB) | Preview |
OBJECTIVE
To elaborate the associations of different cycle regimens (natural cycle = NC, stimulated cycle = SC, hormone replacement cycle = HRC) on maternal and neonatal adverse pregnancy outcomes after frozen-thawed embryo transfers (FET).
DESIGN
Population-based registry study.
SETTING
Swiss IVF Registry.
POPULATION OR SAMPLE
Singleton (n = 4636) and twin life births (n = 544) after NC-FET (n = 776), SC-FET (n = 758) or HRC-FET (n = 3646) registered from 2014 to 2019.
METHODS
Fifteen pregnancy pathologies were modelized for singleton and twin pregnancies using mixed models adjusted for cycle regimen, delivery, fertilization technique, chronic anovulation, age of mother and centre.
MAIN OUTCOME MEASURES
Maternal (vaginal bleeding, isolated arterial hypertension and preeclampsia) and neonatal (gestational age, birthweight, mode of delivery) adverse pregnancy outcomes.
RESULTS
In singleton pregnancies, the incidences of bleeding in first trimester, isolated hypertension and preeclampsia were highest in HRC-FET with doubled odds of bleeding in first trimester (adjusted odds ratio = aOR 2.23; 95% CI 1.33-3.75), isolated hypertension (aOR 2.50; 95% CI 1.02-6.12) and preeclampsia (aOR 2.16; 95% CI 1.13-4.12) in HRC-FET vs. NC-FET and with doubled respectively sixfold odds of bleeding (aOR 2.08; 95% CI 1.03-4.21) and preeclampsia (6.02; 95% CI 1.38-26.24) in HRC-FET vs. SC-FET. In twin pregnancies, the incidence of preeclampsia was highest in HRC-FET with numerically higher odds of preeclampsia in HRC-FET vs. NC-FET and vs. SC-FET.
CONCLUSIONS
Our data implied the highest maternal risks of hypertensive disorders in HRC-FET, therefore clinicians should prefer SC-FET or NC-FET if medically possible.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
Pape, Janna, von Wolff, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1471-0528 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
15 Nov 2022 09:55 |
Last Modified: |
14 Nov 2023 00:25 |
Publisher DOI: |
10.1111/1471-0528.17343 |
PubMed ID: |
36371677 |
Uncontrolled Keywords: |
Frozen-thawed embryo transfer cycle regimen hypertensive disorder preeclampsia twin pregnancy |
BORIS DOI: |
10.48350/174741 |
URI: |
https://boris.unibe.ch/id/eprint/174741 |
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