Hitz, Felicitas; Lang, Noémie; Mey, Ulrich; Mingrone, Walter; Moccia, Alden; Taverna, Christian; Novak, Urban; Stenner, Frank; Schmidt, Adrian; Mamot, Christoph; Fischer, Natalie; Putora, Paul M (2023). Decision-making among experts in advanced Hodgkin Lymphoma. Oncology, 101(3), pp. 159-165. Karger 10.1159/000526360
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BACKGROUND
In the treatment of advanced Hodgkin Lymphoma (aHL), based on guidelines a multitude of treatment options are available. The availability of PET guided decision-making and new therapeutic agents increase the complexity of the decision-making process.
METHODS
Thirteen experts of Swiss university and cantonal hospitals in Switzerland were asked to describe their institutional decision-making practice in aHL. Variables influencing the decision-making process were identified, standardized and converted into decision trees for analysis of consent and discrepancies. The algorithms of all participating experts were analyzed with the objective consensus methodology.
RESULTS
Four decision criteria (age, fertility preservation, fitness, interim PET) and 12 unique treatment regimens were identified. Consensus for the treatment of aHL for young and fit, as well as for older patients without comorbidity was found. Large heterogeneity was identified with use of a variety of different regimens for unfit patients with aHL and for young female patients with a desire of fertility preservation.
CONCLUSION
Four major decision criteria were identified allowing the representation of expert's approach to first-line treatment of aHL. Among Swiss experts, consensus for a PET guided curative treatment of aHL was identified. The use of a multitude of treatment regimens was observed for older and comorbid (unfit) aHL patients, highlighting the need for clinical trials and recommendations for this group of patients.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Novak, Urban, Putora, Paul Martin |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1423-0232 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Rebeka Gerber |
Date Deposited: |
18 Nov 2022 15:47 |
Last Modified: |
04 Mar 2023 00:13 |
Publisher DOI: |
10.1159/000526360 |
PubMed ID: |
36103806 |
BORIS DOI: |
10.48350/174915 |
URI: |
https://boris.unibe.ch/id/eprint/174915 |
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