Significance of Barrier Membrane on the Reconstructive Therapy of Peri-Implantitis: A Randomized Controlled Trial.

Monje, Alberto; Pons, Ramón; Vilarrasa, Javi; Nart, José; Wang, Hom-Lay (2023). Significance of Barrier Membrane on the Reconstructive Therapy of Peri-Implantitis: A Randomized Controlled Trial. Journal of periodontology, 94(3), pp. 323-335. American Academy of Periodontology 10.1002/JPER.22-0511

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OBJECTIVE

To investigate the clinical and radiographic significance of using a mixture of mineralized and demineralized allografts in combination (M) or not (NM) with a resorbable cross-linked barrier membrane in the reconstructive therapy of peri-implantitis defects.

METHODS

A two-arm randomized clinical trial was performed in patients diagnosed with peri-implantitis that exhibited contained defects. Clinical parameters were recorded at baseline (T₀ ), 6 months (T₁ ) and 12 months (T₂ ). Radiographic parameters were recorded at T₀ and T₂ . A composite criteria for disease resolution was defined a priori. A generalized linear model (GLM) of repeated measures with generalized estimation equations (GEE) statistical methods were used.

RESULTS

Overall, 33 patients (n_implants = 48) completed the study. At T₂ , mean disease resolution was 77.1%. The use of a barrier membrane did not enhance the probability of disease resolution at T₂ (OR = 1.55, p = 0.737). Conversely, the odds of disease resolution were statistically associated with modified plaque index (mPI) recorded at T₀ (OR = 0.13, p = 0.006) and keratinized mucosa (KM) width (OR = 2.10, p = 0.035). Moreover, women exhibited greater odds to show disease resolution (OR = 5.56, p = 0.02).

CONCLUSION

Reconstructive therapy by means of a mixture of mineralized and demineralized allografts is effective in clinically resolving peri-implantitis and in gaining radiographic marginal bone level. The addition of a barrier membrane to reconstructive therapy of peri-implantitis does not seem to enhance the outcomes of contained bone defects (NCT05282667). This article is protected by copyright. All rights reserved.

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