van Donge, Tamara; Staub, Eveline; Atkinson, Andrew; Gotta, Verena; van den Anker, John; Risch, Lorenz; Welzel, Tatjana; Pfister, Marc (2020). Age appropriate reference intervals for eight kidney function and injury markers in infants, children and adolescents. Clinical chemistry and laboratory medicine, 59(2), pp. 373-382. Walter de Gruyter 10.1515/cclm-2020-0781
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Objectives
The use of kidney function and injury markers for early detection of drug-related glomerular or tubular kidney injury in infants, children and adolescents requires age-specific data on reference intervals in a pediatric healthy population. This study characterizes serum values for eight kidney function and injury markers in healthy infants, children and adolescents.
Methods
A single center prospective observational study was conducted between December 2018 and June 2019. Serum samples from 142 healthy infants, children and adolescents aged between 0 and ≤15 years were collected. Statistical analyses for eight markers (albumin (ALB), β2-microglobulin (B2M), β-trace protein (BTP), creatinine (SCR), cystatin C (CYSC), kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), uromodulin (URO)) were performed to obtain reference intervals and associations with age, sex and weight were investigated (Pearson correlation, linear and piecewise regression).
Results
ALB and SCR increased with age (p<0.01), whereas B2M, BTP and KIM-1 values decreased with advancing age (p<0.05) in this healthy pediatric study population. CYSC showed dependency on sex (lower concentration in females) and decreased with age until reaching approximately 1.8 years; thereafter an increase with age was seen. NGAL and URO did not show any age-dependency.
Conclusions
This study provides age appropriate reference intervals for key serum kidney function and injury markers determined in healthy infants, children and adolescents. Such reference intervals facilitate the interpretation of changes in kidney function and injury markers in daily practice, and allow early detection of glomerular and tubular injury in infancy, childhood and adolescence.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry |
UniBE Contributor: |
Risch, Lorenz |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1434-6621 |
Publisher: |
Walter de Gruyter |
Language: |
English |
Submitter: |
Karin Balmer |
Date Deposited: |
23 Nov 2022 07:51 |
Last Modified: |
02 Feb 2023 15:42 |
Publisher DOI: |
10.1515/cclm-2020-0781 |
PubMed ID: |
32759403 |
Uncontrolled Keywords: |
age-dependency kidney biomarker kidney injury pediatrics reference intervals |
BORIS DOI: |
10.48350/175000 |
URI: |
https://boris.unibe.ch/id/eprint/175000 |
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